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MeSH Review

Diffusion Chambers, Culture

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Disease relevance of Diffusion Chambers, Culture


High impact information on Diffusion Chambers, Culture

  • Polymorphonuclear leukocytes (PMN) purified from tissue cage fluid had poor bactericidal activity against a catalase-positive microorganism [6].
  • To define the immunopathogenic mechanisms that lead to the development of extravascular lesions such as arthritis, we implanted a tissue cage subcutaneously in arthritic MRL/l mice and compared components of the tissue cage fluid, which resembles the extravascular fluid, with those of sera [7].
  • Quantitation of retroviral gp70 antigen, autoantibodies, and immune complexes in extravascular space in arthritic MRL-lpr/lpr mice. Use of a subcutaneously implanted tissue cage model [7].
  • The pharmacokinetic properties of danofloxacin in serum, inflamed tissue cage fluid (exudate), and noninflamed tissue cage fluid (transudate) were established by using a tissue cage model [8].
  • The q.d. and b.i.d. regimens of levofloxacin had equivalent activities and were significantly (P < 0.05) more active than alatrofloxacin or vancomycin in decreasing the viable counts of MRSA in tissue cage fluids [9].

Chemical compound and disease context of Diffusion Chambers, Culture


Biological context of Diffusion Chambers, Culture


Anatomical context of Diffusion Chambers, Culture


Associations of Diffusion Chambers, Culture with chemical compounds

  • In contrast to their initially different actions, the effects of the antibiotics were similar after 7 days, mostly because bacterial regrowth occurred more frequently in the fleroxacin-treated than in the vancomycin-treated tissue cages [3].
  • The different activities of ciprofloxacin compared with those of the other two quinolones against chronic tissue cage infections caused by MRSA did not involve the selective emergence of quinolone-resistant mutants [21].
  • Active levels of sparfloxacin, temfloxacin, or ciprofloxacin were continuously present in tissue cage fluid during therapy, exceeding their MBCs for MRSA by 6- to 20-fold [21].
  • The penetration of norfloxacin into both infected and uninfected tissue cage fluid was significantly higher on treatment days 3 and 7 than on treatment day 1 [22].
  • Higher concentrations of cefmetazole than cefazolin were found in infected tissue cages at day 3 (5.9 +/- 0.7 versus 2.2 +/- 0.3 micrograms/ml; P < 0.01), day 5 (9.1 +/- 2.6 versus 3.6 +/- 0.7 micrograms/ml; P = 0.02), and day 8 (9.4 +/- 1.4 versus 4.8 +/- 0.9 micrograms/ml; P = 0.01) after infection [23].

Gene context of Diffusion Chambers, Culture

  • When compared with those of sera, tissue cage fluids from arthritic MRL/l mice had similar levels of RF and one-third the amount of C1q immune complexes [7].
  • Furthermore, injection of murine recombinant TNF into tissue cages could substitute for the bacterial components in preventing experimental infection by S. aureus [16].
  • To evaluate how CMDBS could interfere with S. epidermidis attachment to coverslips coated in vivo with extracellular matrix components, we also tested PMMA surfaces retrieved from tissue cages subcutaneously implanted in guinea pigs [24].
  • The osteogenic diffusion chamber culture of rodent marrow cells is a well established system [25].

Analytical, diagnostic and therapeutic context of Diffusion Chambers, Culture

  • Rifampin, alone and in combination with fleroxacin or vancomycin, was the most effective regimen in reducing the bacterial counts in the tissue cage fluids [(1.87 +/- 1.44, 2.18 +/- 1.02, and 2.55 +/- 1.09 log10) CFU/ml, P less than 0.001, respectively] [26].
  • Each enantiomer was administered separately (1.5 mg/kg) and in a racemic mixture (3 mg/kg) intravenously (i.v.) to a group of eight sheep in a four-way, four-period cross-over study using a tissue cage model of inflammation [27].


  1. Alanylation of teichoic acids protects Staphylococcus aureus against Toll-like receptor 2-dependent host defense in a mouse tissue cage infection model. Kristian, S.A., Lauth, X., Nizet, V., Goetz, F., Neumeister, B., Peschel, A., Landmann, R. J. Infect. Dis. (2003) [Pubmed]
  2. Streptococcus pneumoniae response to repeated moxifloxacin or levofloxacin exposure in a rabbit tissue cage model. Xuan, D., Zhong, M., Mattoes, H., Bui, K.Q., McNabb, J., Nicolau, D.P., Quintiliani, R., Nightingale, C.H. Antimicrob. Agents Chemother. (2001) [Pubmed]
  3. Successful single-dose prophylaxis of Staphylococcus aureus foreign body infections in guinea pigs by fleroxacin. Bouchenaki, N., Vaudaux, P.E., Huggler, E., Waldvogel, F.A., Lew, D.P. Antimicrob. Agents Chemother. (1990) [Pubmed]
  4. Pharmacokinetic/pharmacodynamic relationship of danofloxacin against Mannheimia haemolytica in a tissue-cage model in calves. Greko, C., Finn, M., Franklin, A., Bengtsson, B. J. Antimicrob. Chemother. (2003) [Pubmed]
  5. Postantibiotic effect and postantibiotic sub-mic effect of dirithromycin and erythromycin against respiratory tract pathogenic bacteria. Dornbusch, K., Olofsson, C., Holm, S. APMIS (1999) [Pubmed]
  6. Pathogenesis of foreign body infection. Evidence for a local granulocyte defect. Zimmerli, W., Lew, P.D., Waldvogel, F.A. J. Clin. Invest. (1984) [Pubmed]
  7. Quantitation of retroviral gp70 antigen, autoantibodies, and immune complexes in extravascular space in arthritic MRL-lpr/lpr mice. Use of a subcutaneously implanted tissue cage model. Dayer, E., Yoshida, H., Izui, S., Lambert, P.H. Arthritis Rheum. (1987) [Pubmed]
  8. Pharmacokinetics (PK), pharmacodynamics (PD), and PK-PD integration of danofloxacin in sheep biological fluids. Aliabadi, F.S., Landoni, M.F., Lees, P. Antimicrob. Agents Chemother. (2003) [Pubmed]
  9. Comparison of levofloxacin, alatrofloxacin, and vancomycin for prophylaxis and treatment of experimental foreign-body-associated infection by methicillin-resistant Staphylococcus aureus. Vaudaux, P., Francois, P., Bisognano, C., Schrenzel, J., Lew, D.P. Antimicrob. Agents Chemother. (2002) [Pubmed]
  10. Azithromycin in an experimental Staphylococcus aureus abscess model. Bamberger, D.M., Herndon, B.L., Suvarna, P.R. J. Antimicrob. Chemother. (1995) [Pubmed]
  11. Comparative efficacy of daptomycin and vancomycin in the therapy of experimental foreign body infection due to Staphylococcus aureus. Vaudaux, P., Francois, P., Bisognano, C., Li, D., Lew, D.P., Schrenzel, J. J. Antimicrob. Chemother. (2003) [Pubmed]
  12. Distribution of oxytetracycline to tissue cages and granuloma pouches in calves and effect of acute inflammation on distribution to tissue cages. Bengtsson, B., Luthman, J., Jacobsson, S.O., Ekman, S. J. Vet. Pharmacol. Ther. (1991) [Pubmed]
  13. Hydroxyurea (HU) in experimental hematology. II. Similarities and dissimilarities between HU and 3H-thymidine killing. Benestad, H.B. Exp. Hematol. (1977) [Pubmed]
  14. Effects of phenylbutazone on extravascular diffusion, protein binding and urinary excretion of cefazolin in rabbits. Carbon, C., Contrepois, A., Nivoche, Y., Grandjean, M., Decourt, S., Chau, N.P. J. Pharmacol. Exp. Ther. (1981) [Pubmed]
  15. A tissue cage model for the study of prostaglandin kinetics in cattle. Kindahl, H., Seguin, B., Jacobsson, S.O., Luthman, J. Acta Vet. Scand. (1985) [Pubmed]
  16. Contribution of tumor necrosis factor to host defense against staphylococci in a guinea pig model of foreign body infections. Vaudaux, P., Grau, G.E., Huggler, E., Schumacher-Perdreau, F., Fiedler, F., Waldvogel, F.A., Lew, D.P. J. Infect. Dis. (1992) [Pubmed]
  17. The use of stem cell assays to monitor the proliferative potential of bone marrow cells. Quesenberry, P., Levitt, L., Monette, F., Eichacker, P.Q., Zuckerman, K., Sullivan, R., Ryan, M. Exp. Hematol. (1979) [Pubmed]
  18. Pharmacokinetics and pharmacodynamics of fenleuton, a 5-lipoxygenase inhibitor, in ponies. Marr, K., Marsh, K., Hernandez, L., Cunningham, F.M., Lees, P. Res. Vet. Sci. (1998) [Pubmed]
  19. Problems of long-term cannulation of cisterna magna and subarachnoid space in the conscious dog.--Technical note--. Richling, B., Takacs, F. Neurosurgical review. (1982) [Pubmed]
  20. In vivo induction of granulopoiesis in visceral yolk-sac cells by foetal hepatic factors. Anckaert, M.A., Symann, M. Journal of embryology and experimental morphology. (1983) [Pubmed]
  21. Comparison of sparfloxacin, temafloxacin, and ciprofloxacin for prophylaxis and treatment of experimental foreign-body infection by methicillin-resistant Staphylococcus aureus. Cagni, A., Chuard, C., Vaudaux, P.E., Schrenzel, J., Lew, D.P. Antimicrob. Agents Chemother. (1995) [Pubmed]
  22. Norfloxacin penetration into subcutaneous tissue cage fluid in rabbits and efficacy in vivo. Rylander, M., Norrby, S.R. Antimicrob. Agents Chemother. (1983) [Pubmed]
  23. beta-Lactamase-mediated inactivation and efficacy of cefazolin and cefmetazole in Staphylococcus aureus abscesses. Fields, M.T., Herndon, B.L., Bamberger, D.M. Antimicrob. Agents Chemother. (1993) [Pubmed]
  24. Inhibition by heparin and derivatized dextrans of Staphylococcus epidermidis adhesion to in vitro fibronectin-coated or explanted polymer surfaces. Francois, P., Letourneur, D., Lew, D.P., Jozefonwicz, J., Vaudaux, P. Journal of biomaterials science. Polymer edition. (1999) [Pubmed]
  25. Osteogenesis in in vivo diffusion chamber cultures of human marrow cells. Bab, I., Passi-Even, L., Gazit, D., Sekeles, E., Ashton, B.A., Peylan-Ramu, N., Ziv, I., Ulmansky, M. Bone and mineral. (1988) [Pubmed]
  26. Treatment of experimental foreign body infection caused by methicillin-resistant Staphylococcus aureus. Lucet, J.C., Herrmann, M., Rohner, P., Auckenthaler, R., Waldvogel, F.A., Lew, D.P. Antimicrob. Agents Chemother. (1990) [Pubmed]
  27. Enantiospecific pharmacokinetics and pharmacodynamics of ketoprofen in sheep. Landoni, M.F., Comas, W., Mucci, N., Anglarilli, G., Bidal, D., Lees, P. J. Vet. Pharmacol. Ther. (1999) [Pubmed]
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