Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

DAMPA 4-[(2,4-diaminopteridin-6- yl)methyl-methyl...

Synonyms: S1584_Selleck, SureCN221621, AG-J-62591, DC326, NSC-131463, ...

Ahern, M.J. et al., Ellenberger, T.E. et al.

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Disease relevance of AIDS-006954

The concentrations of methotrexate, 2,4 diamino-N(10)-methylpteroic acid, and methotrexate polyglutamate were markedly increased in the samples obtained from the three patients who recorded the greatest increase in fibrosis [1].

High impact information on AIDS-006954

Wild-type and drug-resistant Leishmania major hydrolyze methotrexate to N-10-methyl-4-deoxy-4-aminopteroate without accumulation of methotrexate polyglutamates [2].

References

Hepatic methotrexate content and progression of hepatic fibrosis: preliminary findings. Ahern, M.J., Kevat, S., Hill, W., Hayball, P.J., Harley, H., Hall, P.D. Ann. Rheum. Dis. (1991) [Pubmed]
Wild-type and drug-resistant Leishmania major hydrolyze methotrexate to N-10-methyl-4-deoxy-4-aminopteroate without accumulation of methotrexate polyglutamates. Ellenberger, T.E., Wright, J.E., Rosowsky, A., Beverley, S.M. J. Biol. Chem. (1989) [Pubmed]

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