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Chemical Compound Review: 

Azoxybacilin     [(3S)-3-amino-3-carboxy- propyl]...

Synonyms: AG-K-66126, CHEBI:65461, KST-1A1830, CTK4C9547, AR-1A3233, ...
 
 
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Disease relevance of AIDS-027814

 

High impact information on AIDS-027814

  • The IC50 values of azoxybacilin antifungal activity against Saccharomyces cerevisiae were significantly greater when amino acids containing sulfur were added to the growth medium, whereas other amino acids were not effective at all [2].
  • Synthesis and structure-activity relationships of a novel antifungal agent, azoxybacilin [3].
  • These four intermediates were the same as those required for the growth of the O-acetylhomoserine sulfhydrylase mutant, S. cerevisiae ONO726, indicating that azoxybacilin would inhibit a step or steps in the sulfur-fixation pathway [2].

References

  1. Azoxybacilin, a novel antifungal agent produced by Bacillus cereus NR2991. Production, isolation and structure elucidation. Fujiu, M., Sawairi, S., Shimada, H., Takaya, H., Aoki, Y., Okuda, T., Yokose, K. J. Antibiot. (1994) [Pubmed]
  2. A new methionine antagonist that has antifungal activity: mode of action. Aoki, Y., Kondoh, M., Nakamura, M., Fujii, T., Yamazaki, T., Shimada, H., Arisawa, M. J. Antibiot. (1994) [Pubmed]
  3. Synthesis and structure-activity relationships of a novel antifungal agent, azoxybacilin. Ohwada, J., Umeda, I., Ontsuka, H., Aoki, Y., Shimma, N. Chem. Pharm. Bull. (1994) [Pubmed]
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