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Chemical Compound Review:

CHEMBL6210 1-cyclopropyl-7-[3- (ethylaminomethyl)pyrro...

Synonyms: CI-948, AG-K-11852, SureCN8922444, AC1L2JQJ, CTK5I0635, ...

Jacobs, M.R., Khardori, N. et al.

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Disease relevance of CI-948

Temafloxacin, ciprofloxacin, and PD 117558 were more active than other fluoroquinolones against Mycobacterium avium complex, with 90% minimal bactericidal concentrations (MBC90S; 8-16 micrograms/mL) four- to eightfold greater than 90% minimal inhibitory concentrations (MIC90S; 2 micrograms/mL) [1].

High impact information on CI-948

The three new quinolones, PD 117558, PD 117596 and PD 112739, inhibited 90% of N. asteroides at 1 to 2 micrograms/ml, and two new aminoglycosides, SCH 21420 and SCH 22591, inhibited 90% of N. asteroides at 2 to 4 micrograms/ml [2].

References

Evaluation of the bactericidal activity of temafloxacin. Jacobs, M.R. Am. J. Med. (1991) [Pubmed]
In vitro antimicrobial susceptibilities of Nocardia species. Khardori, N., Shawar, R., Gupta, R., Rosenbaum, B., Rolston, K. Antimicrob. Agents Chemother. (1993) [Pubmed]

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