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Chemical Compound Review

Omniflox     1-(2,4-difluorophenyl)-6- fluoro-7-(3...

Synonyms: Temafloxacin, Temafloxacina, Temafloxacine, Temafloxacinum, SureCN48095, ...
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Disease relevance of Omniflox


High impact information on Omniflox


Chemical compound and disease context of Omniflox


Biological context of Omniflox


Anatomical context of Omniflox


Associations of Omniflox with other chemical compounds


Gene context of Omniflox

  • Amikacin, the 4-quinolone compounds--ciprofloxacin, temafloxacin and PD 117558--and the penem SCH 34343 were active against most of the isolates [26].
  • In contrast sparfloxacin and temafloxacin caused progressive decreases in zymosan and PMA-induced, luminol-dependent PMN CL which reached statistical significance at the higher concentrations [27].
  • The in-vitro activity of clarithromycin, temafloxacin, and ethambutol were assessed by MIC, FIC and intra-macrophage killing determinations alone and in various combinations against ten pigmented and ten non-pigmented strains of Mycobacterium avium complex bacteria [28].
  • Sera from the patient without temafloxacin-dependent red cell antibodies reacted with red cells in the presence of quinine [29].

Analytical, diagnostic and therapeutic context of Omniflox


  1. Activity of temafloxacin and other fluoroquinolones against typical and atypical community-acquired respiratory tract pathogens. Hardy, D.J. Am. J. Med. (1991) [Pubmed]
  2. Recent developments in the treatment of sexually transmitted diseases. Mogabgab, W.J. Am. J. Med. (1991) [Pubmed]
  3. Treatment of chronic bacterial prostatitis with temafloxacin. Cox, C.E., Childs, S.J. Am. J. Med. (1991) [Pubmed]
  4. Comparative penetration of selected fluoroquinolones into respiratory tract fluids and tissues. Wise, R. Am. J. Med. (1991) [Pubmed]
  5. In vitro activity of temafloxacin against gram-positive cocci including methicillin-resistant Staphylococcus aureus. Fuchs, P.C. Am. J. Med. (1991) [Pubmed]
  6. Evaluation of the bactericidal activity of temafloxacin. Jacobs, M.R. Am. J. Med. (1991) [Pubmed]
  7. The influence of age on the pharmacokinetics of temafloxacin. Granneman, G.R., Guay, D.R. Am. J. Med. (1991) [Pubmed]
  8. Treatment of uncomplicated urinary tract infections with temafloxacin. Iravani, A. Am. J. Med. (1991) [Pubmed]
  9. Comparison of organ-specific toxicity of temafloxacin in animals and humans. Krasula, R.W., Pernet, A.G. Am. J. Med. (1991) [Pubmed]
  10. In vitro activity of temafloxacin against gram-negative bacteria: an overview. Hardy, D.J. Am. J. Med. (1991) [Pubmed]
  11. Single-dose oral temafloxacin versus parenteral ceftriaxone in the treatment of gonococcal urethritis/cervicitis. Mogabgab, W.J. Am. J. Med. (1991) [Pubmed]
  12. In vitro activities of three of the newer quinolones against anaerobic bacteria. Wexler, H.M., Molitoris, E., Finegold, S.M. Antimicrob. Agents Chemother. (1992) [Pubmed]
  13. In vivo efficacy of trovafloxacin (CP-99,219), a new quinolone with extended activities against gram-positive pathogens, Streptococcus pneumoniae, and Bacteroides fragilis. Girard, A.E., Girard, D., Gootz, T.D., Faiella, J.A., Cimochowski, C.R. Antimicrob. Agents Chemother. (1995) [Pubmed]
  14. Comparative pharmacokinetics of ciprofloxacin and temafloxacin in humans: a review. Sorgel, F., Naber, K.G., Kinzig, M., Mahr, G., Muth, P. Am. J. Med. (1991) [Pubmed]
  15. The effect of food on the bioavailability of temafloxacin. A review of 3 studies. Granneman, G.R., Mukherjee, D. Clinical pharmacokinetics. (1992) [Pubmed]
  16. Temafloxacin does not potentiate the anticoagulant effect of warfarin in healthy subjects. Millar, E., Coles, S., Wyld, P., Nimmo, W. Clinical pharmacokinetics. (1992) [Pubmed]
  17. Absence of drug interaction between temafloxacin and low dose heparin. Mant, T., Morrison, P., Millar, E. Clinical pharmacokinetics. (1992) [Pubmed]
  18. Temafloxacin: an overview. Pankey, G.A. Am. J. Med. (1991) [Pubmed]
  19. Dextranase enhances antibiotic efficacy in experimental viridans streptococcal endocarditis. Mghir, A.S., Cremieux, A.C., Jambou, R., Muffat-Joly, M., Pocidalo, J.J., Carbon, C. Antimicrob. Agents Chemother. (1994) [Pubmed]
  20. Penetration of temafloxacin into body tissues and fluids. Sörgel, F. Clinical pharmacokinetics. (1992) [Pubmed]
  21. Effect of temafloxacin on the pharmacokinetics of theophylline. Ruff, F., Santais, M.C., Callens, E., Chauvin, J.P., Hazebroucq, J. Am. J. Med. (1991) [Pubmed]
  22. Assessment of temafloxacin neurotoxicity in rodents. Giardina, W.J. Am. J. Med. (1991) [Pubmed]
  23. In vitro activities of lomefloxacin and temafloxacin against pathogens causing diarrhea. Segreti, J., Nelson, J.A., Goodman, L.J., Kaplan, R.L., Trenholme, G.M. Antimicrob. Agents Chemother. (1989) [Pubmed]
  24. Effect of cimetidine on the pharmacokinetics of temafloxacin. Sörgel, F., Granneman, G.R., Stephan, U., Locke, C. Clinical pharmacokinetics. (1992) [Pubmed]
  25. Comparative, double-blind, prospective, multicenter trial of temafloxacin versus trimethoprim-sulfamethoxazole in uncomplicated urinary tract infections in women. Iravani, A. Antimicrob. Agents Chemother. (1991) [Pubmed]
  26. Comparative in-vitro activity of twenty antimicrobial agents against clinical isolates of Mycobacterium avium complex. Khardori, N., Rolston, K., Rosenbaum, B., Hayat, S., Bodey, G.P. J. Antimicrob. Chemother. (1989) [Pubmed]
  27. Effect of newer quinolones on the extra- and intra-cellular chemiluminescence response of human polymorphonuclear leucocytes. Aoki, M., Ono, Y., Kunii, O., Goldstein, E. J. Antimicrob. Chemother. (1994) [Pubmed]
  28. In-vitro evaluation of clarithromycin, temafloxacin, and ethambutol in combination against Mycobacterium avium complex. Gevaudan, M.J., Bollet, C., Mallet, M.N., de Micco, P. J. Antimicrob. Chemother. (1993) [Pubmed]
  29. Hemolytic anemia and acute renal failure associated with temafloxacin-dependent antibodies. Maguire, R.B., Stroncek, D.F., Gale, E., Yearlsey, M. Am. J. Hematol. (1994) [Pubmed]
  30. Oral temafloxacin compared to norfloxacin for the treatment of complicated urinary tract infections. Cox, C.E. Am. J. Med. (1991) [Pubmed]
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