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Chemical Compound Review:

Phenylsulfate sulfooxybenzene

Synonyms: aryl sulfate, SureCN138895, Phenol sulfate, CHEBI:27905, AR-1L5776, ...

Valentine, J.L. et al., Konishi-Imamura, L. et al., Konishi-Imamura, L. et al., Ogata, M. et al., Wells, M.S. et al., et al.

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High impact information on sulfooxybenzene

In addition, a significantly greater percentage of total urinary radioactivity could be accounted for as phenylsulfate conjugates in cyp2e1-/- mice compared to wild-type mice, indicating the importance of CYP2E1 in oxidation of phenol following benzene exposure in normal mice [1].
The AUC of phenylsulfate (detoxification pathway) was proportional to the exposure concentration in both species [2].
Arylsulfate sulfotransferase (ASST) from a human intestinal bacterium stoichiometrically catalyzed the transfer of a sulfate group from phenylsulfate esters to phenolic compounds [3].
The reductions in spleen weight and white blood cell numbers correlated with the concentration of phenylsulfate in the blood, but are most probably not causally related [4].

Gene context of sulfooxybenzene

Arylsulfate sulfotransferase (ASST) from a human intestinal bacterium stoichiometrically catalyzed the transfer of the sulfate group of phenylsulfate esters to phenolic compounds [5].

Analytical, diagnostic and therapeutic context of sulfooxybenzene

High performance liquid chromatography for the quantitative determination of urinary phenylsulfate and phenylglucuronide as indices of benzene and phenol exposure in rats [6].

References

Reduction of benzene metabolism and toxicity in mice that lack CYP2E1 expression. Valentine, J.L., Lee, S.S., Seaton, M.J., Asgharian, B., Farris, G., Corton, J.C., Gonzalez, F.J., Medinsky, M.A. Toxicol. Appl. Pharmacol. (1996) [Pubmed]
Effect of exposure concentration, exposure rate, and route of administration on metabolism of benzene by F344 rats and B6C3F1 mice. Sabourin, P.J., Bechtold, W.E., Griffith, W.C., Birnbaum, L.S., Lucier, G., Henderson, R.F. Toxicol. Appl. Pharmacol. (1989) [Pubmed]
Regulation of arylsulfate sulfotransferase from a human intestinal bacterium by nucleotides and magnesium ion. Konishi-Imamura, L., Kim, D.H., Koizumi, M., Kobashi, K. J. Enzym. Inhib. (1995) [Pubmed]
Hematotoxicity and concentration-dependent conjugation of phenol in mice following inhalation exposure to benzene. Wells, M.S., Nerland, D.E. Toxicol. Lett. (1991) [Pubmed]
Improved purification of arylsulfate sulfotransferase from human intestinal bacterium by using polyclonal antibody. Konishi-Imamura, L., Dohi, K., Sato, M., Kobashi, K. J. Biochem. (1994) [Pubmed]
High performance liquid chromatography for the quantitative determination of urinary phenylsulfate and phenylglucuronide as indices of benzene and phenol exposure in rats. Ogata, M., Yamasaki, Y. International archives of occupational and environmental health. (1979) [Pubmed]

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