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Chemical Compound Review:

PNOT 2-methyl-5-nitro-aniline

Synonyms: SureCN2313, PubChem14022, PubChem14491, CCRIS 483, AGN-PC-0CXJH3, ...

McCormick, N.G. et al., Shimizu, H. et al., Mori, M. et al., Oh, S.Y. et al.

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Disease relevance of Scarlet Base Ciba II

Liver dysfunction among workers handling 5-nitro-o-toluidine [1].
While other aromatic compounds are known to damage the human liver and are registered as toxic substances, toxicity information concerning 5-nitro-o-toluidine is lacking [1].

High impact information on Scarlet Base Ciba II

The products of microbial transformation of 2,4-dinitrotoluene by Mucrosporium sp. were identified by thin-layer chromatography and by gas chromatography/mass spectrometry as 2-amino-4-nitrotoluene, 4-amino-2-nitrotoluene, 2,2'-dinitro-4,4'-azoxytoluene, 4,4'-dinitro-2,2'-azoxytoluene, and 4-acetamido-2-nitrotoluene [2].
In addition to different kinetics and adsorption patterns, the distribution of two intermediates, 4-amino-2-nitrotoluene (4A2NT) and 2-amino-4-nitrotoluene (2A4NT), contrasted sharply [3].

Analytical, diagnostic and therapeutic context of Scarlet Base Ciba II

Data obtained from thin-layer and high-pressure liquid chromatography indicated that metabolites produced by microsomal preparations were 2-amino-4-nitrotoluene (2A4NT) and its isomer (4A2NT) [4].

References

Liver dysfunction among workers handling 5-nitro-o-toluidine. Shimizu, H., Kumada, T., Nakano, S., Kiriyama, S., Sone, Y., Honda, T., Watanabe, K., Nakano, I., Fukuda, Y., Hayakawa, T. Gut (2002) [Pubmed]
Identification of biotransformation products from 2,4-dinitrotoluene. McCormick, N.G., Cornell, J.H., Kaplan, A.M. Appl. Environ. Microbiol. (1978) [Pubmed]
Graphite-mediated reduction of 2,4-dinitrotoluene with elemental iron. Oh, S.Y., Cha, D.K., Chiu, P.C. Environ. Sci. Technol. (2002) [Pubmed]
Reduction of 2,4-dinitrotoluene by Wistar rat liver microsomal and cytosol fractions. Mori, M., Matsuhashi, T., Miyahara, T., Shibata, S., Izima, C., Kozuka, H. Toxicol. Appl. Pharmacol. (1984) [Pubmed]

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