Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

P-BROMOANILINE 4-bromoaniline

Synonyms: PubChem3724, CHEMBL57376, SureCN45481, NSC-7085, ACMC-1BVWU, ...

Scarfe, G.B. et al., Nicholson, J.K. et al., Turcant, A. et al.

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Disease relevance of p-Bromophenylamine

Methemoglobinemia could result from metabolization of metobromuron to bromoaniline and bromoacetanilide [1].

High impact information on p-Bromophenylamine

3. The major metabolite present in urine was 2-amino-5-bromophenylsulphate, but, in addition, a number of metabolites with modification of the N-acetyl moiety were identified (from both the [(13)C]-acetanilide or produced following acetylation of the free bromoaniline) [2].

Associations of p-Bromophenylamine with other chemical compounds

Bromoacetanilide probably results from acetylation of the intermediate bromoaniline [1].

Analytical, diagnostic and therapeutic context of p-Bromophenylamine

High-performance liquid chromatography and inductively coupled plasma mass spectrometry (HPLC-ICP-MS) for the analysis of xenobiotic metabolites in rat urine: application to the metabolites of 4-bromoaniline [3].

References

Acute metobromuron poisoning with severe associated methemoglobinemia. Identification of four metabolites in plasma and urine by LC-DAD, LC-ESI-MS, and LC-ESI-MS-MS. Turcant, A., Cailleux, A., Le Bouil, A., Allain, P., Harry, P., Renault, A. Journal of analytical toxicology. (2000) [Pubmed]
Identification of the urinary metabolites of 4-bromoaniline and 4-bromo-[carbonyl-13C]-acetanilide in rat. Scarfe, G.B., Nicholson, J.K., Lindon, J.C., Wilson, I.D., Taylor, S., Clayton, E., Wright, B. Xenobiotica (2002) [Pubmed]
High-performance liquid chromatography and inductively coupled plasma mass spectrometry (HPLC-ICP-MS) for the analysis of xenobiotic metabolites in rat urine: application to the metabolites of 4-bromoaniline. Nicholson, J.K., Lindon, J.C., Scarfe, G., Wilson, I.D., Abou-Shakra, F., Castro-Perez, J., Eaton, A., Preece, S. The Analyst. (2000) [Pubmed]

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