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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Methemoglobinemia


Psychiatry related information on Methemoglobinemia


High impact information on Methemoglobinemia


Chemical compound and disease context of Methemoglobinemia


Biological context of Methemoglobinemia


Anatomical context of Methemoglobinemia


Gene context of Methemoglobinemia


Analytical, diagnostic and therapeutic context of Methemoglobinemia


  1. A novel point mutation in a 3' splice site of the NADH-cytochrome b5 reductase gene results in immunologically undetectable enzyme and impaired NADH-dependent ascorbate regeneration in cultured fibroblasts of a patient with type II hereditary methemoglobinemia. Shirabe, K., Landi, M.T., Takeshita, M., Uziel, G., Fedrizzi, E., Borgese, N. Am. J. Hum. Genet. (1995) [Pubmed]
  2. Acute methemoglobinemia and hemolytic anemia with phenazopyridine: possible relation to acute renal failure. Nathan, D.M., Siegel, A.J., Bunn, H.F. Arch. Intern. Med. (1977) [Pubmed]
  3. Respiratory insufficiency from dapsone-induced methemoglobinemia. Gallant, J.E., Hoehn-Saric, E., Smith, M.D. AIDS (1991) [Pubmed]
  4. Comparison of metabolism and toxicity to the structure of the anticancer agent sulofenur and related sulfonylureas. Ehlhardt, W.J., Woodland, J.M., Worzalla, J.F., Bewley, J.R., Grindey, G.B., Todd, G.C., Toth, J.E., Howbert, J.J. Chem. Res. Toxicol. (1992) [Pubmed]
  5. Metoclopramide-induced methemoglobinemia. Kearns, G.L., Fiser, D.H. Pediatrics (1988) [Pubmed]
  6. Lipids of liver, kidney, spleen and muscle in a case of generalized deficiency of cytochrome b5 reductase in congenital methemoglobinemia with mental retardation. Hirono, H. Lipids (1984) [Pubmed]
  7. Methemoglobinemia due to riluzole. Viallon, A., Page, Y., Bertrand, J.C. N. Engl. J. Med. (2000) [Pubmed]
  8. Primaquine-induced methemoglobinemia during treatment of Pneumocystis carinii pneumonia. Kantor, G.S. N. Engl. J. Med. (1992) [Pubmed]
  9. Dapsone-induced methemoglobinemia in a patient with P. carinii pneumonia and AIDS. Reiter, W.M., Cimoch, P.J. N. Engl. J. Med. (1987) [Pubmed]
  10. Congenital methemoglobinemia with a deficiency of cytochrome b5. Hegesh, E., Hegesh, J., Kaftory, A. N. Engl. J. Med. (1986) [Pubmed]
  11. Letter: Nitroprusside and methemoglobinemia. Smith, R.P., Carleton, R.A. N. Engl. J. Med. (1976) [Pubmed]
  12. Methemoglobinemia after sodium nitroprusside therapy. Bower, P.J., Peterson, J.N. N. Engl. J. Med. (1975) [Pubmed]
  13. Methemoglobinemia resulting from absorption of nitrates. Harris, J.C., Rumack, B.H., Peterson, R.G., McGuire, B.M. JAMA (1979) [Pubmed]
  14. Methemoglobinemia from overdose of nitroglycerin. Marshall, J.B., Ecklund, R.E. JAMA (1980) [Pubmed]
  15. Methemoglobinemia after sulfametoxazole and trimethoprim. Damergis, J.A., Stoker, J.M., Abadie, J.L. JAMA (1983) [Pubmed]
  16. Mechanisms of methylene blue stimulation of the hexose monophosphate shunt in erythrocytes. Metz, E.N., Balcerzak, P., Sagone, A.L. J. Clin. Invest. (1976) [Pubmed]
  17. The structure of the S127P mutant of cytochrome b5 reductase that causes methemoglobinemia shows the AMP moiety of the flavin occupying the substrate binding site. Bewley, M.C., Davis, C.A., Marohnic, C.C., Taormina, D., Barber, M.J. Biochemistry (2003) [Pubmed]
  18. Human health effects of agrichemical use. Weisenburger, D.D. Hum. Pathol. (1993) [Pubmed]
  19. Pharmacokinetics of sodium nitrite-induced methemoglobinemia in the rat. Kohn, M.C., Melnick, R.L., Ye, F., Portier, C.J. Drug Metab. Dispos. (2002) [Pubmed]
  20. Clinically significant methemoglobinemia from inhalation of isobutyl nitrite. Guss, D.A., Normann, S.A., Manoguerra, A.S. The American journal of emergency medicine. (1985) [Pubmed]
  21. Hypotensive effects of hydroxylamine in intact anesthetized dogs and cats. Kruszyna, R., Kruszyna, H., Doherty, P.A., Smith, R.P. Arch. Toxicol. (1984) [Pubmed]
  22. NADH cytochrome b5 reductase activity in lymphoid cell lines. Expression of the defect in epstein Barr virus transformed lymphoblastoid cell lines from patients with recessive congenital methemoglobinemia. Lostanlen, D., Lenoir, G., Kaplan, J.C. J. Clin. Invest. (1981) [Pubmed]
  23. Hereditary methemoglobinemia due to cytochrome b5 reductase deficiency in blood cells without associated neurologic and mental disorders. Tanishima, K., Tanimoto, K., Tomoda, A., Mawatari, K., Matsukawa, S., Yoneyama, Y., Ohkuwa, H., Takazakura, E. Blood (1985) [Pubmed]
  24. Acute methemoglobinemia induced by topical benzocaine and lidocaine. O'Donohue, W.J., Moss, L.M., Angelillo, V.A. Arch. Intern. Med. (1980) [Pubmed]
  25. Decrease of palmitoyl-CoA elongation in platelets and leukocytes in the patient of hereditary methemoglobinemia associated with mental retardation. Takeshita, M., Tamura, M., Kugi, M., Matsuki, T., Yoneyama, Y., Igarashi, T. Biochem. Biophys. Res. Commun. (1987) [Pubmed]
  26. Methemoglobinemia due to ingestion of N,N-dimethyl-p-toluidine, a component used in the fabrication of artificial fingernails. Potter, J.L., Krill, C.E., Neal, D., Kofron, W.G. Annals of emergency medicine. (1988) [Pubmed]
  27. Decrease in 4-aminobiphenyl-induced methemoglobinemia in Cyp1a2(-/-) knockout mice. Shertzer, H.G., Dalton, T.P., Talaska, G., Nebert, D.W. Toxicol. Appl. Pharmacol. (2002) [Pubmed]
  28. Associated red cell enzyme deficiencies and their significance in a case of congenital enzymopenic methemoglobinemia. Das Gupta, A., Vaidya, M.S., Bapat, J.P., Pavri, R.S., Baxi, A.J., Advani, S.H. Acta Haematol. (1980) [Pubmed]
  29. Exonic point mutations in NADH-cytochrome B5 reductase genes of homozygotes for hereditary methemoglobinemia, types I and III: putative mechanisms of tissue-dependent enzyme deficiency. Katsube, T., Sakamoto, N., Kobayashi, Y., Seki, R., Hirano, M., Tanishima, K., Tomoda, A., Takazakura, E., Yubisui, T., Takeshita, M. Am. J. Hum. Genet. (1991) [Pubmed]
  30. Treatment of high-risk, refractory acquired methemoglobinemia with automated red blood cell exchange. Golden, P.J., Weinstein, R. Journal of clinical apheresis. (1998) [Pubmed]
  31. Methylene blue-induced phototoxicity: an unrecognized complication. Porat, R., Gilbert, S., Magilner, D. Pediatrics (1996) [Pubmed]
  32. Topical benzocaine (Hurricaine) induced methemoglobinemia during endoscopic procedures in gastric bypass patients. Srikanth, M.S., Kahlstrom, R., Oh, K.H., Fox, S.R., Fox, E.R., Fox, K.M. Obesity surgery : the official journal of the American Society for Bariatric Surgery and of the Obesity Surgery Society of Australia and New Zealand. (2005) [Pubmed]
  33. Evaluation of pulse oximetry in anemia from hemoglobin-H disease. Jay, G.D., Renzi, F.P. Annals of emergency medicine. (1992) [Pubmed]
  34. Acute methemoglobinemia during cardiopulmonary bypass caused by intravenous nitroglycerin infusion. Robicsek, F. J. Thorac. Cardiovasc. Surg. (1985) [Pubmed]
  35. Suspected severe methemoglobinemia caused by topical application of an ointment containing benzocaine around the enterostomy. Adachi, T., Fukumoto, M., Uetsuki, N., Yasui, O., Hayashi, M. Anesth. Analg. (1999) [Pubmed]
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