Disease relevance of Pentylene glycol

• Pentane-1,5-diol has low oral toxicity, is essentially non-irritating to the skin and has high antimicrobial activities against bacteria, fungi and viruses [1].
• The in vitro activity of pentane-1,5-diol against aerobic bacteria. A new antimicrobial agent for topical usage [1]?
• Treatment of atopic dermatitis with 1% hydrocortisone and 25% pentane-1,5-diol: effect on Staphylococcus aureus [2].
• The effect of pentane-1,5-diol against both sensitive and multi-resistant Gram-positive and Gram-negative bacteria was tested in vitro against 85 bacterial strains showing minimal inhibitory concentrations in the range of 2.5 to 15.0% (vol/vol) against both antibiotic-susceptible and multi-resistant aerobic bacteria [1].

High impact information on Pentylene glycol

• Pentane-1,5-diol as a percutaneous absorption enhancer [3].

Biological context of Pentylene glycol

• When used in pharmaceutical topical preparations, pentane-1,5-diol will increase the percutaneous absorption of the active substance and it is an efficient antimicrobial agent that will act as an effective preservative in topical formulations [3].

Associations of Pentylene glycol with other chemical compounds

• The release of TRIAC was 21% higher when pentane-1,5-diol was used as an enhancer instead of propane-1,2-diol [3].

References