Disease relevance of Skin Absorption

• Iodochlorhydroxyquin (I) is used in the treatment of diaper rash and other skin disorders, and is presumed to undergo little or no percutaneous absorption [1].
• Dermal dose-ChE response (toxicity) and percutaneous absorption of parathion and carbaryl were studied in the rat [2].
• Influence of age and severity of dermatitis on the percutaneous absorption of hydrocortisone in children [3].
• The potential hazards of repeated topical application of salicylic acid under occlusion to large areas of the body was evaluated by measuring the percutaneous absorption and serum salicylate concentrations in four patients with active psoriasis [4].
• We believe that the triad of HIV infection, medications that reduce seizure thresholds, and percutaneous absorption factors, in the aggregate, induced the seizure [5].

High impact information on Skin Absorption

• Percutaneous absorption of cyclosporin [6].
• Intravenous nicotine retards transdermal absorption of nicotine: evidence of blood flow--limited percutaneous absorption [7].
• Influence of tretinoin on the percutaneous absorption of minoxidil from an aqueous topical solution [8].
• Nineteen healthy male volunteers completed a three-way, randomized, crossover study to determine the effect of the synthetic retinoid, tretinoin, on percutaneous absorption of minoxidil [8].
• We have performed in vivo measurements of near-infrared rat skin absorption in the 4000-5000-cm(-1) spectral range (2.0-2.5-microm wavelength) during a glucose clamp experiment in order to identify the presence of glucose-specific spectral information [9].

Chemical compound and disease context of Skin Absorption

• The percutaneous absorption and metabolism of lonapalene (6-chloro-2,3-dimethoxynaphthalene-1,4-diol-diacetate; RS-43179), a topically effective 5-lipoxygenase inhibitor, has been measured in six subjects with stable plaque-type psoriasis of the lower extremities [10].
• The particularities of percutaneous absorption of a natural androgen, 5 alpha-dihydrotestosterone, were evaluated in substitutive androgen therapy in masculine hypogonadism [11].
• The prerequisite for sensitization and elicitation of an allergic contact dermatitis to gold is ionization and percutaneous absorption of the allergen [12].
• A case of mild phenol toxicity resulting from percutaneous absorption in a dog is reported [13].
• Dermal toxicity and percutaneous absorption of cadmium in rats and mice [14].

Biological context of Skin Absorption

• Biomembrane model interaction and percutaneous absorption of papaverine through rat skin: effects of cyclodextrins as penetration enhancers [15].
• This article reports the results of an open-label, multiple-dose study to determine percutaneous absorption and pharmacokinetics of eflornithine following topical treatment with eflornithine HCl 13.9% cream (Vaniqa) [16].
• Phenol poisoning can occur by skin absorption, vapor inhalation, or ingestion, and, regardless of route of exposure, can result in detrimental health effects [17].
• The percutaneous absorption of betahistine (BH) from a gel formulation containing negatively charged liposomes of BH was much more than that from the formulation with positively charged ones, with 2-fold higher AUC (p<0.05) [18].
• OBJECTIVE: To correlate skin absorption and elimination kinetics of four cyclic terpenes, namely alpha-pinene, beta-pinene, eucalyptol and terpinen-4-ol, applied as neat substance with their physicochemical properties [19].

Anatomical context of Skin Absorption

• Improved delivery through biological membranes XD: Percutaneous absorption and metabolism of methylsulfinylmethyl 2-acetoxybenzoate and related aspirin prodrugs [20].
• Topical triethanolamine 14C-salicylate was found capable of percutaneous absorption into the knee joint and surrounding tissues [21].
• Pharmacodynamic measurements of methyl nicotinate percutaneous absorption: the effect of aging on microcirculation [22].
• It was apparent that percutaneous absorption was taking place and that most of the ketoprofen was predominately localised in fibroblasts in the papillary dermis [23].
• The percutaneous absorption of diflucortolone-21-valerate (DFV) and its effect on the pituitary adrenal system were investigated during large skin area treatment (20 g ointment twice a day for 8 days) of two groups of healthy volunteers with Nerisona and Nerisalic ointment, respectively [24].

Associations of Skin Absorption with chemical compounds

• The percutaneous absorption of four steroids (hydrocortisone, estradiol, testosterone, and progesterone) has been measured in vivo in man under occluded and "protected" (i.e., covered, but non-occlusive) conditions [25].
• Occlusion significantly increased percutaneous absorption of estradiol, testosterone, and progesterone but did not effect the penetration of hydrocortisone [25].
• Percutaneous absorption of iodochlorhydroxyquin in humans [1].
• The objective of this investigation was to develop a new methodology using 19F-magnetic resonance spectroscopy (MRS) to measure the in vivo percutaneous absorption of flurbiprofen through hairless rat skin [26].
• Effect of sodium lauryl sulfate-induced skin irritation on in vitro percutaneous absorption of four drugs [27].

Gene context of Skin Absorption

• Percutaneous absorption of biologically-active interferon-gamma in a human skin graft-nude mouse model [28].
• Percutaneous absorption and anti-inflammatory effect of a substance P receptor antagonist: spantide II [29].
• Strain differences in the induction of EOD by clobetasol propionate were not related to differences in either the concentration of cytosolic glucocorticoid receptor in the skin, the dissociation constant of the cytosolic receptor, or differences in percutaneous absorption [30].
• Dieldrin is not in the small class of insecticides that are dangerous to man by skin absorption (such as parathion, arsenicals, DNC) and, at the area dosages needed for locust control, is not dangerous to stock [31].
• RESULTS: Novasome A cream enhanced the percutaneous absorption of PTH (1-34) in human skin in comparison with formulations in propylene glycol or normal saline [32].

Analytical, diagnostic and therapeutic context of Skin Absorption

• High concentrations of estrone are achieved with oral administration, whereas higher concentrations of estradiol are generally achieved after percutaneous absorption [33].
• The purpose of the present study was to compare Franz cells (FC) and microdialysis (MD) for monitoring the skin absorption of salicylic acid (SA) [34].
• 1. The relevance of skin absorption of cis-1,3-dichloropropene (cis-1,3-DCP) vapour as a route of entry compared to inhalatory uptake has been assessed in human volunteers under controlled exposure conditions [35].
• Iontophoresis promotes percutaneous absorption of L-ascorbic acid in rat skin [36].
• Percutaneous absorption of trinitrobenzene: animal models for human skin [37].

References