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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Chemical Compound Review: 

AC1L1A3N     5-[2-carboxy-6-(1,2- dihydroxyethyl)-4,5...

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Disease relevance of KDO2-LIPID-IVA

  • Given the structural similarity of ADP-mannose to ADP-heptose, we examined the possibility that heptosyl transferase I of E. coli (the product of the rfaC gene) catalyzes mannose transfer from ADP-mannose to Kdo2-lipid IVA [1].
 

High impact information on KDO2-LIPID-IVA

  • Strains harboring an insertion mutation in the lpxL(htrB) gene, which encodes the enzyme that normally transfers laurate from lauroyl-ACP to Kdo2-lipid IVA (Clementz, T., Bednarski, J. J., and Raetz, C. R. H. (1996) J. Biol. Chem. 271, 12095-12102) are not defective in the cold-induced palmitoleoyl transferase [2].
  • In cell extracts, the analog ADP-mannose can serve as an alternative donor for RfaC-catalyzed glycosylation of the acceptor, Kdo2-lipid IVA [3].
 

Chemical compound and disease context of KDO2-LIPID-IVA

 

Gene context of KDO2-LIPID-IVA

  • We now report that wild-type E. coli shifted from 30 degrees C to 12 degrees C acquire a novel palmitoleoyl-acyl carrier protein (ACP)-dependent acyltransferase that acts on the key lipid A precursor Kdo2-lipid IVA [2].

References

  1. Lipopolysaccharide core glycosylation in Rhizobium leguminosarum. An unusual mannosyl transferase resembling the heptosyl transferase I of Escherichia coli. Kadrmas, J.L., Brozek, K.A., Raetz, C.R. J. Biol. Chem. (1996) [Pubmed]
  2. Effect of cold shock on lipid A biosynthesis in Escherichia coli. Induction At 12 degrees C of an acyltransferase specific for palmitoleoyl-acyl carrier protein. Carty, S.M., Sreekumar, K.R., Raetz, C.R. J. Biol. Chem. (1999) [Pubmed]
  3. Enzymatic synthesis of lipopolysaccharide in Escherichia coli. Purification and properties of heptosyltransferase i. Kadrmas, J.L., Raetz, C.R. J. Biol. Chem. (1998) [Pubmed]
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