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Chemical Compound Review:

Palatone 3-hydroxy-2-methyl-pyran-4-one

Synonyms: MALTOL, Talmon, Veltol, Vetol, Larixinic acid, ...

Kim, C. et al., Snyder, J.W. et al., Hironishi, M. et al.

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Disease relevance of MALTOL

Prolonged treatments of APT, MAL and Vit E also ablated histopathological evidence of DOX cardiomyopathy [1].
Maltol (3-hydroxy-2-methyl-4-pyrone) toxicity in neuroblastoma cell lines and primary murine fetal hippocampal neuronal cultures [2].

High impact information on MALTOL

Dose- and time-dependent killing of cultured rat hepatocytes was produced by aluminum maltolate (AlM), a neutral, water-soluble complex of aluminum 3-hydroxy-2-methyl-4H-pyran-4-one [3].
The potential role of APT, MAL and Vit E against DOX insult may be explained by the induction of glutathione peroxidase activity accompanied by the inhibition of lipid peroxidation [1].

Gene context of MALTOL

Prolonged treatments with APT, MAL and Vit E significantly reduced the mortality in animals receiving multiple dose of DOX (3 mg/kg x 4) [1].

References

A new antithrombotic agent, aspalatone, attenuated cardiotoxicity induced by doxorubicin in the mouse; possible involvement of antioxidant mechanism. Kim, C., Nam, S.W., Choi, D.Y., Choi, J.H., Park, E.S., Jhoo, W.K., Kim, H.C. Life Sci. (1997) [Pubmed]
Maltol (3-hydroxy-2-methyl-4-pyrone) toxicity in neuroblastoma cell lines and primary murine fetal hippocampal neuronal cultures. Hironishi, M., Kordek, R., Yanagihara, R., Garruto, R.M. Neurodegeneration : a journal for neurodegenerative disorders, neuroprotection, and neuroregeneration. (1996) [Pubmed]
The absence of extracellular calcium potentiates the killing of cultured hepatocytes by aluminum maltolate. Snyder, J.W., Serroni, A., Savory, J., Farber, J.L. Arch. Biochem. Biophys. (1995) [Pubmed]

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