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Chemical Compound Review:

Clorofene 2-benzyl-4-chloro-phenol

Synonyms: Clorofeno, Clorofenum, Clorophene, Neosabenyl, Neosobenil, ...

Davoren, M. et al., Yamarik, T.A., Birnbaum, L.S. et al.

Davoren, Fogarty,

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Disease relevance of NSC59989

A dose-related contact hypersensitivity response to Chlorophene was reported in mice [1].
Prechronic toxicity of o-benzyl-p-chlorophenol in rats and mice [2].

High impact information on NSC59989

In vitro cytotoxicity assessment of the biocidal agents sodium o-phenylphenol, sodium o-benzyl-p-chlorophenol, and sodium p-tertiary amylphenol using established fish cell lines [3].
A 1-year National Toxicology Program (NTP) study concluded that Chlorophene was a cutaneous irritant and a weak skin tumor promoter but had no activity as an initiator or complete carcinogen [1].

Anatomical context of NSC59989

The chemical sodium o-benzyl-p-chlorophenol was consistently ranked the most toxic of the tested compounds with each cell line and the endpoints employed [3].

References

Safety assessment of dichlorophene and chlorophene. Yamarik, T.A. International journal of toxicology. (2004) [Pubmed]
Prechronic toxicity of o-benzyl-p-chlorophenol in rats and mice. Birnbaum, L.S., Deskin, R., Grumbein, S.L., Kurtz, P., Fowler, K.L., Peters, A.C. Fundamental and applied toxicology : official journal of the Society of Toxicology. (1986) [Pubmed]
In vitro cytotoxicity assessment of the biocidal agents sodium o-phenylphenol, sodium o-benzyl-p-chlorophenol, and sodium p-tertiary amylphenol using established fish cell lines. Davoren, M., Fogarty, A.M. Toxicology in vitro : an international journal published in association with BIBRA. (2006) [Pubmed]

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