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Chemical Compound Review:

Carzenid 4-sulfamoylbenzoic acid

Synonyms: Carzenida, Carzenide, Dirnate, Carzenidum, CHEMBL414, ...

Day, Y.S. et al., Nelson, J.J., Myszka, D.G. et al., Sharma, S.K. et al.

Myszka, Abdiche, Arisaka, Byron, Eisenstein, Hensley, Thomson, Lombardo, Schwarz, Stafford, Doyle,

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High impact information on Carzenide

Chick brain membranes were fractionated by affinity chromatography on AH-Sepharose 6MB linked to p-sulfamylbenzoic acid, an inhibitor of carbonic anhydrase [1].
The model system was composed of a well-characterized enzyme-inhibitor pair, namely bovine carbonic anhydrase II (CA II) and 4-carboxybenzenesulfonamide (CBS) [2].
Quantitation of o- and p-sulfamoylbenzoic acid residues in saccharin and its sodium salt is achieved by a method comprising methanolic extraction and high-performance ion exchange chromatography [3].

Analytical, diagnostic and therapeutic context of Carzenide

Interaction data were collected for two arylsulfonamide compounds, 4-carboxybenzenesulfonamide (CBS) and 5-dimethyl-amino-1-naphthalene-sulfonamide (DNSA), binding to the enzyme using surface plasmon resonance, isothermal titration calorimetry, and stopped-flow fluorescence [4].

References

Affinity chromatography of membrane fragments. Separation of carbonic anhydrase-enriched and -depleted brain membranes. Sharma, S.K., Babitch, J.A. J. Chromatogr. (1984) [Pubmed]
The ABRF-MIRG'02 study: assembly state, thermodynamic, and kinetic analysis of an enzyme/inhibitor interaction. Myszka, D.G., Abdiche, Y.N., Arisaka, F., Byron, O., Eisenstein, E., Hensley, P., Thomson, J.A., Lombardo, C.R., Schwarz, F., Stafford, W., Doyle, M.L. Journal of biomolecular techniques : JBT. (2003) [Pubmed]
Quantitation of o- and p-sulfamoylbenzoic acids in commerical saccharin by high-performance liquid chromatography. Nelson, J.J. Journal - Association of Official Analytical Chemists. (1976) [Pubmed]
Direct comparison of binding equilibrium, thermodynamic, and rate constants determined by surface- and solution-based biophysical methods. Day, Y.S., Baird, C.L., Rich, R.L., Myszka, D.G. Protein Sci. (2002) [Pubmed]

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