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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Ion Exchange

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Disease relevance of Ion Exchange


Psychiatry related information on Ion Exchange


High impact information on Ion Exchange

  • The processing activity was partially purified by ion exchange chromatography and sucrose gradient sedimentation [7].
  • Upon fractionation of the postnuclear S100 by chromatography on ion exchange and gel filtration columns, the stimulatory activity copurifies with small ribonucleoprotein particles [8].
  • After ion-exchange chromatography or gel filtration of the conditioned media and measurement of MSA by 3H-thymidine incorporation or radioreceptor assay, MSA again was found in the 3A medium but not in the 3A2 or 61t media [9].
  • These remarkable dynamics of luminal [Ca2+] result from a fast and highly cooperative Ca2+/K+ ion-exchange process rather than from Ca2+ transport into the lumen [10].
  • Amino acid analysis by ion exchange chromatography is just as important an analytical tool in 1986 as it was in the late 1950s, when Moore and Stein first described an automated AAA instrument [11].

Chemical compound and disease context of Ion Exchange


Biological context of Ion Exchange


Anatomical context of Ion Exchange


Associations of Ion Exchange with chemical compounds

  • Refined methods for separating PTC-amino acids on reverse phase columns may pose a challenge to traditional ion exchange techniques [27].
  • Secondary isotope effects were also observed on ion-exchange chromatography, 3H-labelled folates with 3H at the C-9 position eluting fractionally earlier than the corresponding unlabelled or [2-14C]folate from DEAE-cellulose, a behaviour similar to that reported earlier for isotopically labelled 2-aminopurine and several amino acids [28].
  • Conditioned media from cells grown with or without L-triiodothyronine (T3) were treated with an ion exchange resin to remove T3 and were tested for ability to stimulate the division of GH4C1 cells [29].
  • The purification of human C8 in milligram quantities from outdated human serum was achieved by ammonium sulfate precipitation (37.5-50% saturation) and ion exchange column chromatography employing CM-32 cellulose and QAE-Sephadex [30].
  • Excellent correlation of the distribution of Bb protein and cell-spreading activity was found upon purification of Bb by ion-exchange and molecular seive chromatography and alkaline polyacrylamide gel electrophoresis [31].

Gene context of Ion Exchange

  • Gel and ion-exchange chromatography permitted isolation of the SAA polymorphs in homogeneous form [32].
  • Further fractionation with an ion-exchange chromatography revealed Le(b)-positive MUC5AC glycoforms that differed in their receptor properties for different H. pylori strains [33].
  • In order to define the structure of the alpha and beta subunits generated in the lysosome, the alpha, beta a, and beta b polypeptides of hexosaminidase A and B were separated by a combination of molecular sieve and ion exchange high performance liquid chromatography, and amino-terminal sequences were determined [34].
  • Ion exchange by AtNHX1 was inhibited 70% by the amiloride analog ethylisopropyl-amiloride [35].
  • Herein, we show that ion exchange chromatography separates ARF from the major phospholipase D-stimulating cytosolic factor [36].

Analytical, diagnostic and therapeutic context of Ion Exchange


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  7. The 3' end of drosophila histone H3 mRNA is produced by a processing activity in vitro. Price, D.H., Parker, C.S. Cell (1984) [Pubmed]
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  9. Proliferation of Buffalo rat liver cells in serum-free medium does not depend upon multiplication-stimulating activity (MSA). Nissley, S.P., Short, P.A., Rechler, M.M., Podskalny, J.M., Coon, H.G. Cell (1977) [Pubmed]
  10. Role of Ca2+/K+ ion exchange in intracellular storage and release of Ca2+. Nguyen, T., Chin, W.C., Verdugo, P. Nature (1998) [Pubmed]
  11. Analysis in the ion exchange tradition. Ogden, G. Nature (1986) [Pubmed]
  12. Cytochrome aa3 from Nitrosomonas europaea. Dispirito, A.A., Lipscomb, J.D., Hooper, A.B. J. Biol. Chem. (1986) [Pubmed]
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  18. Epibolin: a protein of human plasma that supports epithelial cell movement. Stenn, K.S. Proc. Natl. Acad. Sci. U.S.A. (1981) [Pubmed]
  19. TATA-box DNA binding activity and subunit composition for RNA polymerase III transcription factor IIIB from Xenopus laevis. McBryant, S.J., Meier, E., Leresche, A., Sharp, S.J., Wolf, V.J., Gottesfeld, J.M. Mol. Cell. Biol. (1996) [Pubmed]
  20. Estrogen preferentially stimulates lactosaminoglycan-containing oligosaccharide synthesis in mouse uteri. Dutt, A., Tang, J.P., Carson, D.D. J. Biol. Chem. (1988) [Pubmed]
  21. Nereis cuticle collagen. Proteolysis by marine vibrial and clostridial collagenases. Waite, J.H., Tanzer, M.L., Merkel, J.R. J. Biol. Chem. (1980) [Pubmed]
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  23. Collagen biosynthesis in human neuroblastoma cell lines: evidence for expression of glial cell properties. DeClerck, Y.A., Lee, C. J. Natl. Cancer Inst. (1985) [Pubmed]
  24. Multiple immunoreactive forms of vasoactive intestinal peptide in human colonic mucosa. Dimaline, R., Dockray, G.J. Gastroenterology (1978) [Pubmed]
  25. Regulation of protein kinase activities in PC12 pheochromocytoma cells. Blenis, J., Erikson, R.L. EMBO J. (1986) [Pubmed]
  26. Molecular characterization of synaptophysin, a major calcium-binding protein of the synaptic vesicle membrane. Rehm, H., Wiedenmann, B., Betz, H. EMBO J. (1986) [Pubmed]
  27. PITC derivatives in amino acid analysis. Cohen, S.A., Bidlingmeyer, B.A., Tarvin, T.L. Nature (1986) [Pubmed]
  28. Secondary isotope effects in studies using radiolabelled folate tracers. Connor, M.J., Blair, J.A., Said, H. Nature (1980) [Pubmed]
  29. Thyroid hormone induction of an autocrine growth factor secreted by pituitary tumor cells. Hinkle, P.M., Kinsella, P.A. Science (1986) [Pubmed]
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  32. Heterogeneity of human serum amyloid A proteins. Bausserman, L.L., Herbert, P.N., McAdam, K.P. J. Exp. Med. (1980) [Pubmed]
  33. Strain- and blood group-dependent binding of Helicobacter pylori to human gastric MUC5AC glycoforms. Lindén, S., Nordman, H., Hedenbro, J., Hurtig, M., Borén, T., Carlstedt, I. Gastroenterology (2002) [Pubmed]
  34. Proteolytic processing of pro-alpha and pro-beta precursors from human beta-hexosaminidase. Generation of the mature alpha and beta a beta b subunits. Mahuran, D.J., Neote, K., Klavins, M.H., Leung, A., Gravel, R.A. J. Biol. Chem. (1988) [Pubmed]
  35. The arabidopsis Na+/H+ exchanger AtNHX1 catalyzes low affinity Na+ and K+ transport in reconstituted liposomes. Venema, K., Quintero, F.J., Pardo, J.M., Donaire, J.P. J. Biol. Chem. (2002) [Pubmed]
  36. ADP-ribosylation factor functions synergistically with a 50-kDa cytosolic factor in cell-free activation of human neutrophil phospholipase D. Lambeth, J.D., Kwak, J.Y., Bowman, E.P., Perry, D., Uhlinger, D.J., Lopez, I. J. Biol. Chem. (1995) [Pubmed]
  37. Amino acid sequence analysis of human interleukin 1 (IL-1). Evidence for biochemically distinct forms of IL-1. Cameron, P., Limjuco, G., Rodkey, J., Bennett, C., Schmidt, J.A. J. Exp. Med. (1985) [Pubmed]
  38. The human invariant chain is the core protein of the human class II-associated proteoglycan. Giacoletto, K.S., Sant, A.J., Bono, C., Gorka, J., O'Sullivan, D.M., Quaranta, V., Schwartz, B.D. J. Exp. Med. (1986) [Pubmed]
  39. Identification of functional endothelial protein C receptor in human plasma. Kurosawa, S., Stearns-Kurosawa, D.J., Hidari, N., Esmon, C.T. J. Clin. Invest. (1997) [Pubmed]
  40. A single gene of chloroplast origin codes for mitochondrial and chloroplastic methionyl-tRNA synthetase in Arabidopsis thaliana. Menand, B., Maréchal-Drouard, L., Sakamoto, W., Dietrich, A., Wintz, H. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
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