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Chemical Compound Review

Phenalene     1H-phenalene

Synonyms: Perinaphthene, AG-J-35077, CHEBI:33082, AC1L1SFG, CTK1A4119, ...
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High impact information on Perinaphthene

  • The phenalene derivatives 3 were prepared by cyclization of the aza lactones of the corresponding alpha-N-acetyl amino acids [1].

Analytical, diagnostic and therapeutic context of Perinaphthene

  • Funalenone, a phenalene compound that inhibits type I collagenase (MMP-1), was isolated from mycelium of Aspergillus niger FO-5904 by solvent extaction, ODS column chromatography, Sephadex LH-20 column chromatography and reversed phase HPLC [2].


  1. Synthesis of 2-amido-2,3-dihydro-1H-phenalene derivatives as new conformationally restricted ligands for melatonin receptors. Mathé-Allainmat, M., Gaudy, F., Sicsic, S., Dangy-Caye, A.L., Shen, S., Brémont, B., Benatalah, Z., Langlois, M., Renard, P., Delagrange, P. J. Med. Chem. (1996) [Pubmed]
  2. Funalenone, a novel collagenase inhibitor produced by Aspergillus niger. Inokoshi, J., Shiomi, K., Masuma, R., Tanaka, H., Yamada, H., Omura, S. J. Antibiot. (1999) [Pubmed]
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