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Chemical Compound Review:

Aminozolamide 6-aminobenzothiazole-2- sulfonamide

Synonyms: CHEMBL35118, SureCN9459715, CHEBI:149402, AC1L3QBY, DNC004469, ...

Lewis, R.A. et al., Putnam, M.L. et al., Campbell, D.A. et al., Lewis, R.A. et al.

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Disease relevance of Aminozolamide

Aminozolamide gel. A trial of a topical carbonic anhydrase inhibitor in ocular hypertension [1].

High impact information on Aminozolamide

These results correlate with the IOP measurements after topical infusion; they also showed no difference in the effect of aminozolamide between hepatic-acetylator phenotypes [2].
Results from in vitro experiments established that both the inhibitory activity of aminozolamide against carbonic anhydrase B as well as the penetration rate across excised rabbit corneas were equivalent to ethoxzolamide [3].
These studies suggest that retention of aminozolamide at the active site is inadequate when delivered in a suspension vehicle [4].

Chemical compound and disease context of Aminozolamide

A topical carbonic anhydrase inhibitor, 6-amino-2-benzothiazolesulfonamide (aminozolamide), which is an analogue of ethoxzolamide, was studied in 18 patients with ocular hypertension [1].

References

Aminozolamide gel. A trial of a topical carbonic anhydrase inhibitor in ocular hypertension. Lewis, R.A., Schoenwald, R.D., Barfknecht, C.F., Phelps, C.D. Arch. Ophthalmol. (1986) [Pubmed]
Characterization of arylamine acetyltransferase in the rabbit eye. Campbell, D.A., Schoenwald, R.D., Duffel, M.W., Barfknecht, C.F. Invest. Ophthalmol. Vis. Sci. (1991) [Pubmed]
Ocular disposition of aminozolamide in the rabbit eye. Putnam, M.L., Schoenwald, R.D., Duffel, M.W., Barfknecht, C.F., Segarra, T.M., Campbell, D.A. Invest. Ophthalmol. Vis. Sci. (1987) [Pubmed]
Aminozolamide suspension: the role of the vehicle in a topical carbonic anhydrase inhibitor. Lewis, R.A., Schoenwald, R.D., Barfknecht, C.F. Journal of ocular pharmacology. (1988) [Pubmed]

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