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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Cornea


Psychiatry related information on Cornea


High impact information on Cornea

  • Donor corneas were selected on the basis of ABO-blood-group compatibility, a negative lymphocyte crossmatch, and optimal HLA-A and B matching; all clinical personnel were "masked" to the degree of HLA matching during the study [7].
  • In vivo, leptin induced neovascularization in corneas from normal rats but not in corneas from fa/fa Zucker rats, which lack functional leptin receptors [8].
  • In vivo neutralization of IFN-gamma relieved inflammation at least in part through a specific block of PMN extravasation into HSV-1-infected corneas [9].
  • Histological analysis found that FasL+ grafts contained apoptotic mononuclear cells indicating the induction of apoptosis by the graft, while rejecting FasL- corneas contained numerous inflammatory cells without associated apoptosis [10].
  • VPF promoted the growth of new blood vessels when administered into healing rabbit bone grafts or rat corneas [11].

Chemical compound and disease context of Cornea

  • These results are in agreement with findings of previous biochemical studies, which show reduction of highly sulfated keratan sulfate epitopes in corneas from keratoconus and pellucid marginal degeneration, and absence of sulfated keratan sulfate epitopes in macular corneal dystrophy [3].
  • Fluorescein isothiocyanate-labeled LPS from Escherichia coli was deposited onto the abraded corneas of New Zealand White rabbits [12].
  • Endothelial Na+/K(+)-ATPase pump density, as measured by ouabain binding, showed a statistically significant (P < 0.05) decrease in HSV-1-infected corneas during peak edema compared to mock antigen-injected or uninjected control corneas [13].
  • Synergistic anti-herpes simplex virus type 1 (HSV-1) activity between acyclovir (ACV) and recombinant human interferon alpha A2 (IFN) was detected in cell cultures derived from human corneas [14].
  • Histologically, the manumycin- and gliotoxin-treated corneas showed minimum edema and good epithelialization [15].

Biological context of Cornea


Anatomical context of Cornea


Associations of Cornea with chemical compounds


Gene context of Cornea


Analytical, diagnostic and therapeutic context of Cornea


  1. An essential role for antibody in neutrophil and eosinophil recruitment to the cornea: B cell-deficient (microMT) mice fail to develop Th2-dependent, helminth-mediated keratitis. Hall, L.R., Lass, J.H., Diaconu, E., Strine, E.R., Pearlman, E. J. Immunol. (1999) [Pubmed]
  2. Overexpression of matrix metalloproteinase-10 and matrix metalloproteinase-3 in human diabetic corneas: a possible mechanism of basement membrane and integrin alterations. Saghizadeh, M., Brown, D.J., Castellon, R., Chwa, M., Huang, G.H., Ljubimova, J.Y., Rosenberg, S., Spirin, K.S., Stolitenko, R.B., Adachi, W., Kinoshita, S., Murphy, G., Windsor, L.J., Kenney, M.C., Ljubimov, A.V. Am. J. Pathol. (2001) [Pubmed]
  3. Altered antigenicity of keratan sulfate proteoglycan in selected corneal diseases. Funderburgh, J.L., Funderburgh, M.L., Rodrigues, M.M., Krachmer, J.H., Conrad, G.W. Invest. Ophthalmol. Vis. Sci. (1990) [Pubmed]
  4. Bacteriologic cure of experimental Pseudomonas keratitis. Davis, S.D., Sarff, L.D., Hyndiuk, R.A. Invest. Ophthalmol. Vis. Sci. (1978) [Pubmed]
  5. Herpetic keratitis in experimental vitamin A deficiency. Hatchell, D.L., O'Brien, W.J., Taylor, J.L., Hyndiuk, R.A. Invest. Ophthalmol. Vis. Sci. (1987) [Pubmed]
  6. Apolipoproteins J and E co-localise with amyloid in gelatinous drop-like and lattice type I corneal dystrophies. Nishida, K., Quantock, A.J., Dota, A., Choi-Miura, N.H., Kinoshita, S. The British journal of ophthalmology. (1999) [Pubmed]
  7. Reduced graft rejection with good HLA-A and B matching in high-risk corneal transplantation. Sanfilippo, F., MacQueen, J.M., Vaughn, W.K., Foulks, G.N. N. Engl. J. Med. (1986) [Pubmed]
  8. Biological action of leptin as an angiogenic factor. Sierra-Honigmann, M.R., Nath, A.K., Murakami, C., García-Cardeña, G., Papapetropoulos, A., Sessa, W.C., Madge, L.A., Schechner, J.S., Schwabb, M.B., Polverini, P.J., Flores-Riveros, J.R. Science (1998) [Pubmed]
  9. Interferon gamma regulates platelet endothelial cell adhesion molecule 1 expression and neutrophil infiltration into herpes simplex virus-infected mouse corneas. Tang, Q., Hendricks, R.L. J. Exp. Med. (1996) [Pubmed]
  10. CD95 ligand (FasL)-induced apoptosis is necessary for corneal allograft survival. Stuart, P.M., Griffith, T.S., Usui, N., Pepose, J., Yu, X., Ferguson, T.A. J. Clin. Invest. (1997) [Pubmed]
  11. Tumor vascular permeability factor stimulates endothelial cell growth and angiogenesis. Connolly, D.T., Heuvelman, D.M., Nelson, R., Olander, J.V., Eppley, B.L., Delfino, J.J., Siegel, N.R., Leimgruber, R.M., Feder, J. J. Clin. Invest. (1989) [Pubmed]
  12. Lipopolysaccharide entry in the damaged cornea and specific uptake by polymorphonuclear neutrophils. Schultz, C.L., Buret, A.G., Olson, M.E., Ceri, H., Read, R.R., Morck, D.W. Infect. Immun. (2000) [Pubmed]
  13. Endothelial barrier function and Na+/K(+)-ATPase pump density in herpetic stromal disease. O'Brien, W.J., Palmer, M.L., Guy, J., Taylor, J.L. Invest. Ophthalmol. Vis. Sci. (1996) [Pubmed]
  14. Synergistic antiherpes virus activity of acyclovir and interferon in human corneal stromal cells. Taylor, J.L., Casey, M.S., O'Brien, W.J. Invest. Ophthalmol. Vis. Sci. (1989) [Pubmed]
  15. Inhibition of corneal inflammation by the topical use of Ras farnesyltransferase inhibitors: selective inhibition of macrophage localization. Sonoda, K., Sakamoto, T., Yoshikawa, H., Ashizuka, S., Ohshima, Y., Kishihara, K., Nomoto, K., Ishibashi, T., Inomata, H. Invest. Ophthalmol. Vis. Sci. (1998) [Pubmed]
  16. Galectins-3 and -7, but not galectin-1, play a role in re-epithelialization of wounds. Cao, Z., Said, N., Amin, S., Wu, H.K., Bruce, A., Garate, M., Hsu, D.K., Kuwabara, I., Liu, F.T., Panjwani, N. J. Biol. Chem. (2002) [Pubmed]
  17. The cloning of mouse keratocan cDNA and genomic DNA and the characterization of its expression during eye development. Liu, C.Y., Shiraishi, A., Kao, C.W., Converse, R.L., Funderburgh, J.L., Corpuz, L.M., Conrad, G.W., Kao, W.W. J. Biol. Chem. (1998) [Pubmed]
  18. Requirement for Pax6 in corneal morphogenesis: a role in adhesion. Davis, J., Duncan, M.K., Robison, W.G., Piatigorsky, J. J. Cell. Sci. (2003) [Pubmed]
  19. Activated polyamidoamine dendrimers, a non-viral vector for gene transfer to the corneal endothelium. Hudde, T., Rayner, S.A., Comer, R.M., Weber, M., Isaacs, J.D., Waldmann, H., Larkin, D.F., George, A.J. Gene Ther. (1999) [Pubmed]
  20. Expression of transforming growth factor-beta in wound healing of vitamin A-deficient rat corneas. Hayashi, K., Frangieh, G., Wolf, G., Kenyon, K.R. Invest. Ophthalmol. Vis. Sci. (1989) [Pubmed]
  21. CYR61, a product of a growth factor-inducible immediate early gene, promotes angiogenesis and tumor growth. Babic, A.M., Kireeva, M.L., Kolesnikova, T.V., Lau, L.F. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  22. A herpes simplex virus 1 recombinant lacking the glycoprotein G coding sequences is defective in entry through apical surfaces of polarized epithelial cells in culture and in vivo. Tran, L.C., Kissner, J.M., Westerman, L.E., Sears, A.E. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  23. Intercellular adhesion molecule-1 in human corneal endothelium. Modulation and function. Elner, V.M., Elner, S.G., Pavilack, M.A., Todd, R.F., Yue, B.Y., Huber, A.R. Am. J. Pathol. (1991) [Pubmed]
  24. In situ injury-induced release of basic-fibroblast growth factor from corneal epithelial cells. Adamis, A.P., Meklir, B., Joyce, N.C. Am. J. Pathol. (1991) [Pubmed]
  25. Differential expression of extracellular matrix metalloproteinase inducer (CD147) in normal and ulcerated corneas: role in epithelio-stromal interactions and matrix metalloproteinase induction. Gabison, E.E., Mourah, S., Steinfels, E., Yan, L., Hoang-Xuan, T., Watsky, M.A., De Wever, B., Calvo, F., Mauviel, A., Menashi, S. Am. J. Pathol. (2005) [Pubmed]
  26. Macular corneal dystrophy: failure to synthesize a mature keratan sulfate proteoglycan. Hassell, J.R., Newsome, D.A., Krachmer, J.H., Rodrigues, M.M. Proc. Natl. Acad. Sci. U.S.A. (1980) [Pubmed]
  27. Structurally normal corneas in aldehyde dehydrogenase 3a1-deficient mice. Nees, D.W., Wawrousek, E.F., Robison, W.G., Piatigorsky, J. Mol. Cell. Biol. (2002) [Pubmed]
  28. Cyclooxygenase-2 inhibition by celecoxib reduces proliferation and induces apoptosis in angiogenic endothelial cells in vivo. Leahy, K.M., Ornberg, R.L., Wang, Y., Zweifel, B.S., Koki, A.T., Masferrer, J.L. Cancer Res. (2002) [Pubmed]
  29. Keratocan, a cornea-specific keratan sulfate proteoglycan, is regulated by lumican. Carlson, E.C., Liu, C.Y., Chikama, T., Hayashi, Y., Kao, C.W., Birk, D.E., Funderburgh, J.L., Jester, J.V., Kao, W.W. J. Biol. Chem. (2005) [Pubmed]
  30. Human corneal interleukin-8. IL-1 and TNF-induced gene expression and secretion. Elner, V.M., Strieter, R.M., Pavilack, M.A., Elner, S.G., Remick, D.G., Danforth, J.M., Kunkel, S.L. Am. J. Pathol. (1991) [Pubmed]
  31. Expression of Smad7 in mouse eyes accelerates healing of corneal tissue after exposure to alkali. Saika, S., Ikeda, K., Yamanaka, O., Miyamoto, T., Ohnishi, Y., Sato, M., Muragaki, Y., Ooshima, A., Nakajima, Y., Kao, W.W., Flanders, K.C., Roberts, A.B. Am. J. Pathol. (2005) [Pubmed]
  32. Expression of vascular endothelial growth factor and its receptors in inflamed and vascularized human corneas. Philipp, W., Speicher, L., Humpel, C. Invest. Ophthalmol. Vis. Sci. (2000) [Pubmed]
  33. Prolongation of sheep corneal allograft survival by transfer of the gene encoding ovine IL-12-p40 but not IL-4 to donor corneal endothelium. Klebe, S., Coster, D.J., Sykes, P.J., Swinburne, S., Hallsworth, P., Scheerlinck, J.P., Krishnan, R., Williams, K.A. J. Immunol. (2005) [Pubmed]
  34. Accumulation of beta ig-h3 gene product in corneas with granular dystrophy. Klintworth, G.K., Valnickova, Z., Enghild, J.J. Am. J. Pathol. (1998) [Pubmed]
  35. Regional variation in distribution of EGF receptor in developing and adult corneal epithelium. Zieske, J.D., Wasson, M. J. Cell. Sci. (1993) [Pubmed]
  36. Proteoglycan synthesis by bovine keratocytes and corneal fibroblasts: maintenance of the keratocyte phenotype in culture. Beales, M.P., Funderburgh, J.L., Jester, J.V., Hassell, J.R. Invest. Ophthalmol. Vis. Sci. (1999) [Pubmed]
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