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Chemical Compound Review:

PubChem9259 2-chloro-7H-purin-6-amine

Synonyms: CHEMBL134192, NSC-7362, ACMC-1C6X9, AG-B-90494, AG-E-33542, ...

Hentosh, P. et al., Albertioni, F. et al., Hentosh, P. et al., Bukowska-Maciejewska, A.M. et al., Lindemalm, S. et al., et al.

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High impact information on AIDS-024486

Control (Ade-containing) and 2-chloroadenine (ClAde)-substituted DNA strands that contained a RNA polymerase promoter sequence were synthesized by a modified asymmetric polymerase chain reaction [1].
2-Chloro-2'-deoxyadenosine triphosphate, a purine nucleotide analogue and potent antileukaemic agent, was incorporated into double-stranded 36-mers in place of dATP to investigate the effects of 2-chloroadenine (ClAde) on DNA polymerase-associated 3'-->5' exonuclease activity [2].
A reversed-phase high-performance liquid chromatographic (HPLC) method for the simultaneous determination of a new and promising anticancer drug, 2-chloro-2'-deoxyadenosine (CdA), and its metabolite, 2-chloroadenine (CAde), in plasma and urine was developed [3].
Cytotoxicity and pharmacokinetics of cladribine metabolite, 2-chloroadenine in patients with leukemia [4].
The mean bioavailability was only 21% due to deglycosylation of CdA to 2-chloroadenine (CAde) [5].

Biological context of AIDS-024486

Since this drug is incorporated into DNA, we have undertaken studies on base pairing of 2-chloroadenine (2ClA) [6].

References

In vitro transcription of DNA containing 2-chloro-2'-deoxyadenosine monophosphate. Hentosh, P., Tibudan, M. Mol. Pharmacol. (1995) [Pubmed]
2-Chloro-2'-deoxyadenosine monophosphate residues in DNA enhance susceptibility to 3'-->5' exonucleases. Hentosh, P., Grippo, P. Biochem. J. (1994) [Pubmed]
Analysis of 2-chloro-2'-deoxyadenosine in human blood plasma and urine by high-performance liquid chromatography using solid-phase extraction. Albertioni, F., Pettersson, B., Reichelová, V., Juliusson, G., Liliemark, J. Therapeutic drug monitoring. (1994) [Pubmed]
Cytotoxicity and pharmacokinetics of cladribine metabolite, 2-chloroadenine in patients with leukemia. Lindemalm, S., Liliemark, J., Juliusson, G., Larsson, R., Albertioni, F. Cancer Lett. (2004) [Pubmed]
Bioavailability and bacterial degradation of rectally administered 2-chloro-2'-deoxyadenosine. Liliemark, J., Albertioni, F., Edlund, C., Juliusson, G. Journal of pharmaceutical and biomedical analysis. (1995) [Pubmed]
Template-directed base pairing of 2-chloro-2'-deoxyadenosine catalyzed by AMV reverse transcriptase. Bukowska-Maciejewska, A.M., Kuśmierek, J.T. Acta Biochim. Pol. (1998) [Pubmed]

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