Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

PubChem15382 2-fluoroaniline

Synonyms: SureCN33295, F3401_ALDRICH, AGN-PC-008TMC, CHEMBL195328, PARAGOS 530123, ...

Vervoort, J. et al., Cnubben, N.H. et al., Vervoort, J. et al.

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High impact information on 1AN

Relationships between the regioselectivity of the hydroxylation of C4-substituted 2-fluoroaniline derivatives and their toxic endpoints [1].
Biotransformation of 2-fluoroaniline in rats studied by in vivo 19F NMR [2].

Anatomical context of 1AN

3. In vitro studies of phase I metabolism of 2-fluoroaniline with rat liver microsomes was representative for the in vivo metabolism as hydroxylation in both systems was observed only at the para-position [3].

References

Relationships between the regioselectivity of the hydroxylation of C4-substituted 2-fluoroaniline derivatives and their toxic endpoints. Cnubben, N.H., van den Berg, C.L., Rietjens, I.M. Toxicol. Appl. Pharmacol. (1996) [Pubmed]
Biotransformation of 2-fluoroaniline in rats studied by in vivo 19F NMR. Vervoort, J., Rietjens, I.M., Moonen, C.T., von Kienlin, M., Despres, D. NMR in biomedicine. (1991) [Pubmed]
Development of a 19F-n.m.r. method for studies on the in vivo and in vitro metabolism of 2-fluoroaniline. Vervoort, J., De Jager, P.A., Steenbergen, J., Rietjens, I.M. Xenobiotica (1990) [Pubmed]

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