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Chemical Compound Review

PubChem15709     2-chloro-N-(2,6- diethylphenyl)ethanamide

Synonyms: CCRIS 7256, AG-A-40532, AG-G-71501, SureCN6769239, ALBB-002266, ...
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High impact information on CCRIS 7256

  • Butachlor is metabolized to CDEPA to a much greater extent by rat liver microsomes (0.045 nmol/min/mg) than by human liver microsomes (< 0.001 nmol/min/mg) [1].
  • We have determined that both rat and human livers metabolize both CMEPA to MEA (0.308 nmol/min/mg and 0.541 nmol/min/mg, respectively) and CDEPA to DEA (0.350 nmol/min/mg and 0.841 nmol/min/mg, respectively) [1].
  • [14C-phenyl]Alachlor is compared to its two metabolic cleavage products, [14C-phenyl]2-chloro-N-(2,6-diethylphenyl)acetamide (CDEPA) [ArNHC(O)CH2Cl] and [14C-phenyl]2,6-diethylaniline (DEA) (ArNH2), and to [14C-methoxy]alachlor in various in vitro and in vivo systems [2].
  • Horseradish peroxidase and hydrogen peroxide activate DEA, but not CDEPA or alachlor, for formation of adducts with calf thymus DNA, which probably involves 2,6-diethylnitrosobenzene (ArNO) as an intermediate [2].

Associations of CCRIS 7256 with other chemical compounds


  1. Comparative metabolism of chloroacetamide herbicides and selected metabolites in human and rat liver microsomes. Coleman, S., Linderman, R., Hodgson, E., Rose, R.L. Environ. Health Perspect. (2000) [Pubmed]
  2. DNA adduct formation by alachlor metabolites. Brown, M.A., Kimmel, E.C., Casida, J.E. Life Sci. (1988) [Pubmed]
  3. In vitro metabolism of alachlor by human liver microsomes and human cytochrome P450 isoforms. Coleman, S., Liu, S., Linderman, R., Hodgson, E., Rose, R.L. Chem. Biol. Interact. (1999) [Pubmed]
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