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Chemical Compound Review

PubChem10751     3-fluoroaniline

Synonyms: CHEMBL58888, SureCN33929, F3606_ALDRICH, PARAGOS 390223, AG-F-30433, ...
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High impact information on m-Fluoroaniline

  • Compound 6b, 3-fluoroaniline derivative, was the most active of the series, with the IC50 less than or equal to 0.16 ng/mL, making it several fold more potent than 1 [1].
  • The compounds 33a,b having a 3-fluoroaniline group at C-4 showed comparable or superior CDK2 inhibitory activity to those of olomoucine and roscovitine as reference compounds [2].
  • Second, it was investigated whether the preferential site for in vitro aromatic hydroxylation of 3-fluoroaniline could be predicted on the basis of the same calculated parameter [3].

Anatomical context of m-Fluoroaniline

  • The results obtained indicated that the variation in the regioselectivity of the aromatic hydroxylation of 3-fluoroaniline by liver microsomes from different species, including man, was only a few percent, and was mainly directed by calculated chemical reactivity characteristics of the 3-fluoraniline substrate [3].


  1. Antimalarial activity of new water-soluble dihydroartemisinin derivatives. 3. Aromatic amine analogues. Lin, A.J., Li, L.Q., Klayman, D.L., George, C.F., Flippen-Anderson, J.L. J. Med. Chem. (1990) [Pubmed]
  2. Synthesis and biological evaluations of pyrazolo[3,4-d]pyrimidines as cyclin-dependent kinase 2 inhibitors. Kim, D.C., Lee, Y.R., Yang, B.S., Shin, K.J., Kim, D.J., Chung, B.Y., Yoo, K.H. European journal of medicinal chemistry. (2003) [Pubmed]
  3. Comparative MO-QSAR studies in various species including man. Tyrakowska, B., Cnubben, N.H., Soffers, A.E., Wobbes, T., Rietjens, I.M. Chem. Biol. Interact. (1996) [Pubmed]
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