Gene Review:
CDK2 - cyclin-dependent kinase 2
Homo sapiens
Synonyms:
CDKN2, Cell division protein kinase 2, Cyclin-dependent kinase 2, p33 protein kinase, p33(CDK2)
- A novel function of adenovirus E1A is required to overcome growth arrest by the CDK2 inhibitor p27(Kip1). Alevizopoulos, K., Catarin, B., Vlach, J., Amati, B. EMBO J. (1998)
- Phosphorylation of progesterone receptor serine 400 mediates ligand-independent transcriptional activity in response to activation of cyclin-dependent protein kinase 2. Pierson-Mullany, L.K., Lange, C.A. Mol. Cell. Biol. (2004)
- Expression of cyclin E renders cyclin D-CDK4 dispensable for inactivation of the retinoblastoma tumor suppressor protein, activation of E2F, and G1-S phase progression. Keenan, S.M., Lents, N.H., Baldassare, J.J. J. Biol. Chem. (2004)
- HIV-1 Tat interaction with RNA polymerase II C-terminal domain (CTD) and a dynamic association with CDK2 induce CTD phosphorylation and transcription from HIV-1 promoter. Deng, L., Ammosova, T., Pumfery, A., Kashanchi, F., Nekhai, S. J. Biol. Chem. (2002)
- Active cyclin A-CDK2 complex, a possible critical factor for cell proliferation in human primary lung carcinomas. Dobashi, Y., Shoji, M., Jiang, S.X., Kobayashi, M., Kawakubo, Y., Kameya, T. Am. J. Pathol. (1998)
- Cdk-Inhibitory Activity and Stability of p27(Kip1) Are Directly Regulated by Oncogenic Tyrosine Kinases. Grimmler, M., Wang, Y., Mund, T., Cilensek, Z., Keidel, E.M., Waddell, M.B., Jäkel, H., Kullmann, M., Kriwacki, R.W., Hengst, L. Cell (2007)
- CDKs promote DNA replication origin licensing in human cells by protecting Cdc6 from APC/C-dependent proteolysis. Mailand, N., Diffley, J.F. Cell (2005)
- Recycling the cell cycle: cyclins revisited. Murray, A.W. Cell (2004)
- Cell proliferation without cyclin E-CDK2. Méndez, J. Cell (2003)
- Limited redundancy in phosphorylation of retinoblastoma tumor suppressor protein by cyclin-dependent kinases in acute lymphoblastic leukemia. Schmitz, N.M., Hirt, A., Aebi, M., Leibundgut, K. Am. J. Pathol. (2006)
- Indole-3-carbinol (I3C) inhibits cyclin-dependent kinase-2 function in human breast cancer cells by regulating the size distribution, associated cyclin E forms, and subcellular localization of the CDK2 protein complex. Garcia, H.H., Brar, G.A., Nguyen, D.H., Bjeldanes, L.F., Firestone, G.L. J. Biol. Chem. (2005)
- CDK2 is a target for retinoic acid-mediated growth inhibition in MCF-7 human breast cancer cells. Teixeira, C., Pratt, M.A. Mol. Endocrinol. (1997)
- Androgen and epidermal growth factor down-regulate cyclin-dependent kinase inhibitor p27Kip1 and costimulate proliferation of MDA PCa 2a and MDA PCa 2b prostate cancer cells. Ye, D., Mendelsohn, J., Fan, Z. Clin. Cancer Res. (1999)
- Crystal structure and mutational analysis of the human CDK2 kinase complex with cell cycle-regulatory protein CksHs1. Bourne, Y., Watson, M.H., Hickey, M.J., Holmes, W., Rocque, W., Reed, S.I., Tainer, J.A. Cell (1996)
- Inhibition of CDK2 activity in vivo by an associated 20K regulatory subunit. Gu, Y., Turck, C.W., Morgan, D.O. Nature (1993)
- Phosphoprotein-protein interactions revealed by the crystal structure of kinase-associated phosphatase in complex with phosphoCDK2. Song, H., Hanlon, N., Brown, N.R., Noble, M.E., Johnson, L.N., Barford, D. Mol. Cell (2001)
- Prolonged induction of p21Cip1/WAF1/CDK2/PCNA complex by epidermal growth factor receptor activation mediates ligand-induced A431 cell growth inhibition. Fan, Z., Lu, Y., Wu, X., DeBlasio, A., Koff, A., Mendelsohn, J. J. Cell Biol. (1995)
- Cyclin A/CDK2 binds directly to E2F-1 and inhibits the DNA-binding activity of E2F-1/DP-1 by phosphorylation. Xu, M., Sheppard, K.A., Peng, C.Y., Yee, A.S., Piwnica-Worms, H. Mol. Cell. Biol. (1994)
- Suppression of centrosome amplification after DNA damage depends on p27 accumulation. Sugihara, E., Kanai, M., Saito, S., Nitta, T., Toyoshima, H., Nakayama, K., Nakayama, K.I., Fukasawa, K., Schwab, M., Saya, H., Miwa, M. Cancer Res. (2006)
- Induction of p18INK4c and its predominant association with CDK4 and CDK6 during myogenic differentiation. Franklin, D.S., Xiong, Y. Mol. Biol. Cell (1996)
- p12(DOC-1) is a novel cyclin-dependent kinase 2-associated protein. Shintani, S., Ohyama, H., Zhang, X., McBride, J., Matsuo, K., Tsuji, T., Hu, M.G., Hu, G., Kohno, Y., Lerman, M., Todd, R., Wong, D.T. Mol. Cell. Biol. (2000)
- Flavopiridol induces G1 arrest with inhibition of cyclin-dependent kinase (CDK) 2 and CDK4 in human breast carcinoma cells. Carlson, B.A., Dubay, M.M., Sausville, E.A., Brizuela, L., Worland, P.J. Cancer Res. (1996)
- G1 phase accumulation induced by UCN-01 is associated with dephosphorylation of Rb and CDK2 proteins as well as induction of CDK inhibitor p21/Cip1/WAF1/Sdi1 in p53-mutated human epidermoid carcinoma A431 cells. Akiyama, T., Yoshida, T., Tsujita, T., Shimizu, M., Mizukami, T., Okabe, M., Akinaga, S. Cancer Res. (1997)
- Degradation of cyclin A does not require its phosphorylation by CDC2 and cyclin-dependent kinase 2. Yam, C.H., Siu, W.Y., Lau, A., Poon, R.Y. J. Biol. Chem. (2000)
- Cyclin E/Cdk2 activity is controlled by different mechanisms in the G0 and G1 phases of the cell cycle. Bresnahan, W.A., Boldogh, I., Ma, T., Albrecht, T., Thompson, E.A. Cell Growth Differ. (1996)
- Cyclin-dependent kinase-2 (Cdk2) forms an inactive complex with cyclin D1 since Cdk2 associated with cyclin D1 is not phosphorylated by Cdk7-cyclin-H. Higashi, H., Suzuki-Takahashi, I., Saitoh, S., Segawa, K., Taya, Y., Okuyama, A., Nishimura, S., Kitagawa, M. Eur. J. Biochem. (1996)
- BRCA1 is phosphorylated at serine 1497 in vivo at a cyclin-dependent kinase 2 phosphorylation site. Ruffner, H., Jiang, W., Craig, A.G., Hunter, T., Verma, I.M. Mol. Cell. Biol. (1999)
- Dephosphorylation of Cdk2 Thr160 by the cyclin-dependent kinase-interacting phosphatase KAP in the absence of cyclin. Poon, R.Y., Hunter, T. Science (1995)
- Protein kinase C inhibits the CAK-CDK2 cyclin-dependent kinase cascade and G1/S cell cycle progression in human diploid fibroblasts. Hamada, K., Takuwa, N., Zhou, W., Kumada, M., Takuwa, Y. Biochim. Biophys. Acta (1996)
- The dynamic mobility of histone H1 is regulated by cyclin/CDK phosphorylation. Contreras, A., Hale, T.K., Stenoien, D.L., Rosen, J.M., Mancini, M.A., Herrera, R.E. Mol. Cell. Biol. (2003)
- p21CIP1 and Cdc25A: competition between an inhibitor and an activator of cyclin-dependent kinases. Saha, P., Eichbaum, Q., Silberman, E.D., Mayer, B.J., Dutta, A. Mol. Cell. Biol. (1997)
- Down-regulation of BRCA1-BARD1 ubiquitin ligase by CDK2. Hayami, R., Sato, K., Wu, W., Nishikawa, T., Hiroi, J., Ohtani-Kaneko, R., Fukuda, M., Ohta, T. Cancer Res. (2005)
- Activation of cyclin-dependent kinase 2 by full length and low molecular weight forms of cyclin E in breast cancer cells. Harwell, R.M., Mull, B.B., Porter, D.C., Keyomarsi, K. J. Biol. Chem. (2004)
- Potent inhibitors of cyclin-dependent kinase 2 induce nuclear accumulation of wild-type p53 and nucleolar fragmentation in human untransformed and tumor-derived cells. David-Pfeuty, T. Oncogene (1999)
- The tumour suppressor gene product APC blocks cell cycle progression from G0/G1 to S phase. Baeg, G.H., Matsumine, A., Kuroda, T., Bhattacharjee, R.N., Miyashiro, I., Toyoshima, K., Akiyama, T. EMBO J. (1995)
- Separate domains of p21 involved in the inhibition of Cdk kinase and PCNA. Chen, J., Jackson, P.K., Kirschner, M.W., Dutta, A. Nature (1995)
- Requirements for cdk7 in the assembly of cdk1/cyclin B and activation of cdk2 revealed by chemical genetics in human cells. Larochelle, S., Merrick, K.A., Terret, M.E., Wohlbold, L., Barboza, N.M., Zhang, C., Shokat, K.M., Jallepalli, P.V., Fisher, R.P. Mol. Cell (2007)
- Cleavage of p21Cip1/Waf1 and p27Kip1 mediates apoptosis in endothelial cells through activation of Cdk2: role of a caspase cascade. Levkau, B., Koyama, H., Raines, E.W., Clurman, B.E., Herren, B., Orth, K., Roberts, J.M., Ross, R. Mol. Cell (1998)
- Structure and regulation of the CDK5-p25(nck5a) complex. Tarricone, C., Dhavan, R., Peng, J., Areces, L.B., Tsai, L.H., Musacchio, A. Mol. Cell (2001)
- Phosphorylation of mammalian CDC6 by cyclin A/CDK2 regulates its subcellular localization. Petersen, B.O., Lukas, J., Sørensen, C.S., Bartek, J., Helin, K. EMBO J. (1999)
- Human cyclin A is required for mitosis until mid prophase. Furuno, N., den Elzen, N., Pines, J. J. Cell Biol. (1999)
- G1 arrest and down-regulation of cyclin E/cyclin-dependent kinase 2 by the protein kinase inhibitor staurosporine are dependent on the retinoblastoma protein in the bladder carcinoma cell line 5637. Schnier, J.B., Nishi, K., Goodrich, D.W., Bradbury, E.M. Proc. Natl. Acad. Sci. U.S.A. (1996)
- Up-regulation of cyclin-dependent kinase 4/cyclin D2 expression but down-regulation of cyclin-dependent kinase 2/cyclin E in testicular germ cell tumors. Schmidt, B.A., Rose, A., Steinhoff, C., Strohmeyer, T., Hartmann, M., Ackermann, R. Cancer Res. (2001)
- Cyclin-Dependent Kinase 2 Functions in Normal DNA Repair and Is a Therapeutic Target in BRCA1-Deficient Cancers. Deans, A.J., Khanna, K.K., McNees, C.J., Mercurio, C., Heierhorst, J., McArthur, G.A. Cancer Res. (2006)