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Chemical Compound Review:

CCRIS 1780 1-(chloromethyl)pyrene

Synonyms: AG-D-25061, ACMC-20990q, ANW-15960, NSC-133487, KB-65035, ...

Glatt, H. et al., Kennelly, J.C. et al.

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High impact information on NSC 133487

Genotoxic activity of 1-chloromethylpyrene in stomach epithelium in vivo: insensitivity of the stomach scintillation UDS assay [1].
When Cl- anions were present at physiological concentrations, an additional reaction product of HMPS, 1-chloromethylpyrene (ClMP), could be identified on the basis of its chromatographic properties and its mass spectrum, using the authentic standard for comparison [2].

References

Genotoxic activity of 1-chloromethylpyrene in stomach epithelium in vivo: insensitivity of the stomach scintillation UDS assay. Kennelly, J.C., Lane, M.P., Barker, J.A., Barber, G., Tinwell, H., Gallagher, J.E., Pool-Zobel, B., Schmezer, P., Ashby, J. Carcinogenesis (1993) [Pubmed]
Sulfotransferase-mediated chlorination of 1-hydroxymethylpyrene to a mutagen capable of penetrating indicator cells. Glatt, H., Henschler, R., Phillips, D.H., Blake, J.W., Steinberg, P., Seidel, A., Oesch, F. Environ. Health Perspect. (1990) [Pubmed]

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