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Chemical Compound Review:

AG-E-97410 2-hydroxydodecanoic acid

Synonyms: CHEBI:36211, H6521_SIGMA, NSC-39025, NSC39025, CTK2G1446, ...

Kawahara, K. et al., Moss, C.W. et al., Kawai, Y. et al.

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Disease relevance of alpha-Hydroxy lauric acid

Although the fatty acid composition of the residual bound lipids of B. parapertussis was similar to that of the residual bound lipids of B. pertussis, 2-hydroxydodecanoic acid was detected only in the bound lipids of B. bronchiseptica [1].
The genus Acinetobacter was differentiated from other organisms in the study by small amounts of 2-hydroxydodecanoic acid (2-OH-12:0), and P. immobilis was differentiated by small amounts of decanoic acid (10:0) and a branched-chain 17-carbon acid (i-17:0) [2].
It was found that Pseudomonas ovalis IAM 1177 had an abundance of hydroxy fatty acids such as 3-hydroxy-decanoic acid, 3-hydroxy-dodecanoic acid and 2-hydroxy-dodecanoic acid in the lipophilic part of the lipopolysaccharide fraction, which comprise 80% of total fatty acids [3].

References

Characteristic lipids of Bordetella pertussis: simple fatty acid composition, hydroxy fatty acids, and an ornithine-containing lipid. Kawai, Y., Moribayashi, A. J. Bacteriol. (1982) [Pubmed]
Cultural and chemical characterization of CDC groups EO-2, M-5, and M-6, Moraxella (Moraxella) species, Oligella urethralis, Acinetobacter species, and Psychrobacter immobilis. Moss, C.W., Wallace, P.L., Hollis, D.G., Weaver, R.E. J. Clin. Microbiol. (1988) [Pubmed]
Direct hydroxylation in the biosynthesis of hydroxy fatty acid in lipid a of Pseudomonas ovalis. Kawahara, K., Uchida, K., Aida, K. Biochim. Biophys. Acta (1979) [Pubmed]

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