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Chemical Compound Review:

O-Methylserine 2-amino-3-methoxy-propanoic acid

Synonyms: AG-E-44622, M7378_SIGMA, ANW-42710, NSC-62335, AC1L3ZLA, ...

Yamada, T. et al., Schubert, C. et al., Sun, L. et al., Hodges, R.S. et al.

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Disease relevance of NSC62335

The holo-SDH contained PLP-OMS aldimine in the active site, indicating that OMS can form the Schiff base linkage with PLP, but the subsequent dehydration did not occur [1].

High impact information on NSC62335

Methods are described for the hydrolysis and quantitative amino acid analysis of peptides containing O-methylserine [2].
Comparison with the rSDH-(PLP-OMS) holo-enzyme reveals a large structural difference in active sites caused by the artifical O-methylserine [3].
The site of methylation, Ser-195 or His-57 (chymotrypsinogen numbering), was determine by analyzing for O-methylserine and methylhistidines [4].

References

Crystal structure of serine dehydratase from rat liver. Yamada, T., Komoto, J., Takata, Y., Ogawa, H., Pitot, H.C., Takusagawa, F. Biochemistry (2003) [Pubmed]
The role of serine-123 in the activity and specificity of ribonuclease. Reactivation of ribonuclease 1-118 by the synthetic COOH-terminal tetradecapeptide, ribonuclease 111-124, and its O-methylserine and alanine analogs. Hodges, R.S., Merrifield, R.B. J. Biol. Chem. (1975) [Pubmed]
Crystal structure of the pyridoxal-5'-phosphate-dependent serine dehydratase from human liver. Sun, L., Bartlam, M., Liu, Y., Pang, H., Rao, Z. Protein Sci. (2005) [Pubmed]
Formation of pi, tau-dimethylhistidine on alkylation of trypsin with active-site-directed sulfonic acid methyl esters. Schubert, C., Fiedler, F. J. Enzym. Inhib. (1994) [Pubmed]

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