Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

AGN-PC-00LB3N (2,3,4,5-tetrahydroxy-6-oxo...

Synonyms: G7772_SIGMA, NSC-170229, AC1Q6RYE, NSC170229, AR-1H2469, ...

Kidder, G.M., Bardosi, A. et al., Kadner, R.J. et al., Hirono, A. et al., van Rooijen, R.J. et al.

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High impact information on D-Galactose 6-phosphate

Expression of both lacA and lacB was required to obtain galactose-6-phosphate isomerase activity [1].
Molecular abnormality of a unique Japanese glucose-6-phosphate dehydrogenase variant (G6PD Kobe) with a greatly increased affinity for galactose-6-phosphate [2].
In all species except the goby, two groups of isozymes were distinguished, corresponding to the mammalian G6PD (specific for glucose-6-phosphate (G6P) and NADP+) and H6PD (capable of utilizing galactose-6-phosphate and in certain cases other monosaccharide phosphates in addition to G6P) [3].
In contrast, addition of 2-deoxyglucose-6-phosphate, galactose-6-phosphate, glucosamine-6-phosphate or arabinose-5-phosphate, which do not directly enter the glycolytic pathway, resulted in growth inhibition without engendering methylglyoxal production or cell death [4].
Among the population of multinucleate giant cells, a positive histochemical reaction was observed with mannose-6-phosphate-, galactose-6-phosphate- and glucuronic acid-(BSA-biotin), respectively, only in giant cells in which fusing mononuclear cells were recognizable [5].

References

Molecular cloning, characterization, and nucleotide sequence of the tagatose 6-phosphate pathway gene cluster of the lactose operon of Lactococcus lactis. van Rooijen, R.J., van Schalkwijk, S., de Vos, W.M. J. Biol. Chem. (1991) [Pubmed]
Molecular abnormality of a unique Japanese glucose-6-phosphate dehydrogenase variant (G6PD Kobe) with a greatly increased affinity for galactose-6-phosphate. Hirono, A., Nakayama, S., Fujii, H., Miwa, S. Am. J. Hematol. (1994) [Pubmed]
Glucose-6-phosphate dehydrogenase isozymes in fish--a comparative study. Kidder, G.M. J. Exp. Zool. (1983) [Pubmed]
Two mechanisms for growth inhibition by elevated transport of sugar phosphates in Escherichia coli. Kadner, R.J., Murphy, G.P., Stephens, C.M. J. Gen. Microbiol. (1992) [Pubmed]
Are glycoconjugates and their endogenous receptors involved in the fusion of mononuclear macrophages resulting in multinucleate giant cells? Histochemical and electron microscopic determination of endogenous sugar-binding proteins (lectins) in mononuclear macrophages and multinucleate giant cells appearing in granulomatous foreign body reaction. Bardosi, A., Dimitri, T., Gabius, H.J. J. Submicrosc. Cytol. Pathol. (1989) [Pubmed]

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