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Gene Review

RASGRP1  -  RAS guanyl releasing protein 1 (calcium...

Homo sapiens

Synonyms: CALDAG-GEFI, CALDAG-GEFII, CalDAG-GEFII, Calcium and DAG-regulated guanine nucleotide exchange factor II, RAS guanyl-releasing protein 1, ...
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High impact information on RASGRP1

  • The expression of CalDAG-GEFI and CalDAG-GEFII in hematopoietic organs suggests that such control may have broad significance in Ras/Rap regulation of normal and malignant states [1].
  • Expression of CalDAG-GEFIII induced neuronal differentiation of PC12 cells and anchorage-independent growth of Rat1A cells less efficiently than did CalDAG-GEFII [2].
  • By contrast, guanine nucleotide exchange of M-Ras was promoted by the guanine nucleotide exchange factors (GEFs) for the classical Ras (Ha-, K-, and N-), including mSos, RasGRF, CalDAG-GEFII, and CalDAG-GEFIII [3].


  1. A Rap guanine nucleotide exchange factor enriched highly in the basal ganglia. Kawasaki, H., Springett, G.M., Toki, S., Canales, J.J., Harlan, P., Blumenstiel, J.P., Chen, E.J., Bany, I.A., Mochizuki, N., Ashbacher, A., Matsuda, M., Housman, D.E., Graybiel, A.M. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  2. CalDAG-GEFIII activation of Ras, R-ras, and Rap1. Yamashita, S., Mochizuki, N., Ohba, Y., Tobiume, M., Okada, Y., Sawa, H., Nagashima, K., Matsuda, M. J. Biol. Chem. (2000) [Pubmed]
  3. Regulatory proteins of R-Ras, TC21/R-Ras2, and M-Ras/R-Ras3. Ohba, Y., Mochizuki, N., Yamashita, S., Chan, A.M., Schrader, J.W., Hattori, S., Nagashima, K., Matsuda, M. J. Biol. Chem. (2000) [Pubmed]
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