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Gene Review:

Rasgrp1 - RAS guanyl releasing protein 1

Mus musculus

Synonyms: CalDAG-GEFII, Calcium and DAG-regulated guanine nucleotide exchange factor II, RAS guanyl-releasing protein 1, Ras guanyl-releasing protein, Rasgrp

Coughlin, J.J. et al., Layer, K. et al.

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Disease relevance of Rasgrp1

As reported previously, older Rasgrp1-/- mice develop splenomegaly and antinuclear Abs as a result of a T cell defect [1].

High impact information on Rasgrp1

Autoimmunity as the consequence of a spontaneous mutation in Rasgrp1 [2].
Using Rasgrp1 and Rasgrp3 single and double null mutant mice, we analyzed the role of these proteins in signaling to Ras and Erk in B cells [1].

References

RasGRP1 and RasGRP3 regulate B cell proliferation by facilitating B cell receptor-Ras signaling. Coughlin, J.J., Stang, S.L., Dower, N.A., Stone, J.C. J. Immunol. (2005) [Pubmed]
Autoimmunity as the consequence of a spontaneous mutation in Rasgrp1. Layer, K., Lin, G., Nencioni, A., Hu, W., Schmucker, A., Antov, A.N., Li, X., Takamatsu, S., Chevassut, T., Dower, N.A., Stang, S.L., Beier, D., Buhlmann, J., Bronson, R.T., Elkon, K.B., Stone, J.C., Van Parijs, L., Lim, B. Immunity (2003) [Pubmed]

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