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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

NME6  -  NME/NM23 nucleoside diphosphate kinase 6

Homo sapiens

Synonyms: IPIA-ALPHA, IPIA-alpha, Inhibitor of p53-induced apoptosis-alpha, NDK 6, NDP kinase 6, ...
 
 
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Disease relevance of NME6

 

High impact information on NME6

  • These findings indicate that nm23-H6, and particularly nm23-H4 and -H7, may be involved in the development of colon and gastric carcinoma, the latter possibly in a type-specific manner [1].
  • Compared to typical proteins of this family such as NME1 and NME2, NME6 has three additional residues located in the Kpn loop, and a 22-residue extension at the COOH-terminal [2].
  • Using radiation hybrid mapping, the NME6 gene was localized to chromosome 3p21 [2].

References

  1. Expression of the nm23 homologues nm23-H4, nm23-H6, and nm23-H7 in human gastric and colon cancer. Seifert, M., Welter, C., Mehraein, Y., Seitz, G. J. Pathol. (2005) [Pubmed]
  2. NME6: a new member of the nm23/nucleoside diphosphate kinase gene family located on human chromosome 3p21.3. Mehus, J.G., Deloukas, P., Lambeth, D.O. Hum. Genet. (1999) [Pubmed]
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