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Gene Review

SPRY3  -  sprouty homolog 3 (Drosophila)

Homo sapiens

Synonyms: HSPRY3, Protein sprouty homolog 3, Spry-3, spry-3
 
 
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High impact information on SPRY3

  • The relatively stable maintenance of SPRY3 silencing compared with SYBL1 suggests that genes without CpG islands may be less prone to reactivation than previously thought and that genes with CpG islands require promoter methylation as an additional layer of repression [1].
  • Maintenance of X- and Y-inactivation of the pseudoautosomal (PAR2) gene SPRY3 is independent from DNA methylation and associated to multiple layers of epigenetic modifications [1].

References

  1. Maintenance of X- and Y-inactivation of the pseudoautosomal (PAR2) gene SPRY3 is independent from DNA methylation and associated to multiple layers of epigenetic modifications. De Bonis, M.L., Cerase, A., Matarazzo, M.R., Ferraro, M., Strazzullo, M., Hansen, R.S., Chiurazzi, P., Neri, G., D'Esposito, M. Hum. Mol. Genet. (2006) [Pubmed]
 
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