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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

DNA Methylation

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Disease relevance of DNA Methylation


Psychiatry related information on DNA Methylation


High impact information on DNA Methylation


Chemical compound and disease context of DNA Methylation


Biological context of DNA Methylation


Anatomical context of DNA Methylation


Associations of DNA Methylation with chemical compounds


Gene context of DNA Methylation

  • We show here that the chief enzyme that maintains mammalian DNA methylation, DNMT1, can also establish a repressive transcription complex [32].
  • To define the mechanism through which demethylated cells die, and to establish a paradigm for identifying genes regulated by DNA methylation, we have generated mice with a conditional allele for the maintenance DNA methyltransferase gene Dnmt1 [33].
  • We suggest that the process of DNA methylation, mediated by Dnmt1, may depend on or generate an altered chromatin state via histone deacetylase activity [34].
  • Regulation of DNA methylation of Rasgrf1 [35].
  • Mutations in ATRX, encoding a SWI/SNF-like protein, cause diverse changes in the pattern of DNA methylation [36].

Analytical, diagnostic and therapeutic context of DNA Methylation


  1. Independent mechanisms involved in suppression of the Moloney leukemia virus genome during differentiation of murine teratocarcinoma cells. Niwa, O., Yokota, Y., Ishida, H., Sugahara, T. Cell (1983) [Pubmed]
  2. Alcohol, low-methionine--low-folate diets, and risk of colon cancer in men. Giovannucci, E., Rimm, E.B., Ascherio, A., Stampfer, M.J., Colditz, G.A., Willett, W.C. J. Natl. Cancer Inst. (1995) [Pubmed]
  3. Epigenetic regulation of 11 beta-hydroxysteroid dehydrogenase type 2 expression. Alikhani-Koopaei, R., Fouladkou, F., Frey, F.J., Frey, B.M. J. Clin. Invest. (2004) [Pubmed]
  4. RNA polymerase alpha subunit binding site in positively controlled promoters: a new model for RNA polymerase-promoter interaction and transcriptional activation in the Escherichia coli ada and aidB genes. Landini, P., Volkert, M.R. EMBO J. (1995) [Pubmed]
  5. Relationship between transient DNA hypomethylation and erythroid differentiation of murine erythroleukemia cells. Razin, A., Levine, A., Kafri, T., Agostini, S., Gomi, T., Cantoni, G.L. Proc. Natl. Acad. Sci. U.S.A. (1988) [Pubmed]
  6. Chronic alcohol consumption induces genomic but not p53-specific DNA hypomethylation in rat colon. Choi, S.W., Stickel, F., Baik, H.W., Kim, Y.I., Seitz, H.K., Mason, J.B. J. Nutr. (1999) [Pubmed]
  7. DNA methylation, nuclear structure, gene expression and cancer. Leonhardt, H., Cardoso, M.C. J. Cell. Biochem. Suppl. (2000) [Pubmed]
  8. Methylation and acetylation in nervous system development and neurodegenerative disorders. Mattson, M.P. Ageing Res. Rev. (2003) [Pubmed]
  9. MEDEA takes control of its own imprinting. Arnaud, P., Feil, R. Cell (2006) [Pubmed]
  10. Evidence for an instructive mechanism of de novo methylation in cancer cells. Keshet, I., Schlesinger, Y., Farkash, S., Rand, E., Hecht, M., Segal, E., Pikarski, E., Young, R.A., Niveleau, A., Cedar, H., Simon, I. Nat. Genet. (2006) [Pubmed]
  11. Short double-stranded RNA induces transcriptional gene silencing in human cancer cells in the absence of DNA methylation. Ting, A.H., Schuebel, K.E., Herman, J.G., Baylin, S.B. Nat. Genet. (2005) [Pubmed]
  12. Histone H1 depletion in mammals alters global chromatin structure but causes specific changes in gene regulation. Fan, Y., Nikitina, T., Zhao, J., Fleury, T.J., Bhattacharyya, R., Bouhassira, E.E., Stein, A., Woodcock, C.L., Skoultchi, A.I. Cell (2005) [Pubmed]
  13. Atypical RNA polymerase subunits required for RNA-directed DNA methylation. Kanno, T., Huettel, B., Mette, M.F., Aufsatz, W., Jaligot, E., Daxinger, L., Kreil, D.P., Matzke, M., Matzke, A.J. Nat. Genet. (2005) [Pubmed]
  14. DNA methylation prevents the amplification of TROP1, a tumor-associated cell surface antigen gene. Alberti, S., Nutini, M., Herzenberg, L.A. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  15. Site and sequence specific DNA methylation in the neurofibromatosis (NF1) gene includes C5839T: the site of the recurrent substitution mutation in exon 31. Andrews, J.D., Mancini, D.N., Singh, S.M., Rodenhiser, D.I. Hum. Mol. Genet. (1996) [Pubmed]
  16. Inhibition of DNA methylation in L1210 leukemic cells by 5-aza-2'-deoxycytidine as a possible mechanism of chemotherapeutic action. Wilson, V.L., Jones, P.A., Momparler, R.L. Cancer Res. (1983) [Pubmed]
  17. Methylated purines in human liver DNA after probable dimethylnitrosamine poisoning. Herron, D.C., Shank, R.C. Cancer Res. (1980) [Pubmed]
  18. Silencing of the hypoxia-inducible cell death protein BNIP3 in pancreatic cancer. Okami, J., Simeone, D.M., Logsdon, C.D. Cancer Res. (2004) [Pubmed]
  19. Mammalian (cytosine-5) methyltransferases cause genomic DNA methylation and lethality in Drosophila. Lyko, F., Ramsahoye, B.H., Kashevsky, H., Tudor, M., Mastrangelo, M.A., Orr-Weaver, T.L., Jaenisch, R. Nat. Genet. (1999) [Pubmed]
  20. DNA methylation controls the inducibility of the mouse metallothionein-I gene lymphoid cells. Compere, S.J., Palmiter, R.D. Cell (1981) [Pubmed]
  21. Maintenance of genomic methylation requires a SWI2/SNF2-like protein. Jeddeloh, J.A., Stokes, T.L., Richards, E.J. Nat. Genet. (1999) [Pubmed]
  22. A protein from human placental nuclei binds preferentially to 5-methylcytosine-rich DNA. Huang, L.H., Wang, R., Gama-Sosa, M.A., Shenoy, S., Ehrlich, M. Nature (1984) [Pubmed]
  23. Reactivation of an inactive human X chromosome: evidence for X inactivation by DNA methylation. Mohandas, T., Sparkes, R.S., Shapiro, L.J. Science (1981) [Pubmed]
  24. Developmental changes in methylation of spermatogenesis-specific genes include reprogramming in the epididymis. Ariel, M., Cedar, H., McCarrey, J. Nat. Genet. (1994) [Pubmed]
  25. Cellular differentiation, cytidine analogs and DNA methylation. Jones, P.A., Taylor, S.M. Cell (1980) [Pubmed]
  26. Gamete-specific methylation correlates with imprinting of the murine Xist gene. Ariel, M., Robinson, E., McCarrey, J.R., Cedar, H. Nat. Genet. (1995) [Pubmed]
  27. A critical role for Dnmt1 and DNA methylation in T cell development, function, and survival. Lee, P.P., Fitzpatrick, D.R., Beard, C., Jessup, H.K., Lehar, S., Makar, K.W., Pérez-Melgosa, M., Sweetser, M.T., Schlissel, M.S., Nguyen, S., Cherry, S.R., Tsai, J.H., Tucker, S.M., Weaver, W.M., Kelso, A., Jaenisch, R., Wilson, C.B. Immunity (2001) [Pubmed]
  28. DNA methylation maintains allele-specific KIR gene expression in human natural killer cells. Chan, H.W., Kurago, Z.B., Stewart, C.A., Wilson, M.J., Martin, M.P., Mace, B.E., Carrington, M., Trowsdale, J., Lutz, C.T. J. Exp. Med. (2003) [Pubmed]
  29. ROS1, a repressor of transcriptional gene silencing in Arabidopsis, encodes a DNA glycosylase/lyase. Gong, Z., Morales-Ruiz, T., Ariza, R.R., Roldán-Arjona, T., David, L., Zhu, J.K. Cell (2002) [Pubmed]
  30. Cancer epigenetics comes of age. Jones, P.A., Laird, P.W. Nat. Genet. (1999) [Pubmed]
  31. Trimethylated lysine 9 of histone H3 is a mark for DNA methylation in Neurospora crassa. Tamaru, H., Zhang, X., McMillen, D., Singh, P.B., Nakayama, J., Grewal, S.I., Allis, C.D., Cheng, X., Selker, E.U. Nat. Genet. (2003) [Pubmed]
  32. DNMT1 binds HDAC2 and a new co-repressor, DMAP1, to form a complex at replication foci. Rountree, M.R., Bachman, K.E., Baylin, S.B. Nat. Genet. (2000) [Pubmed]
  33. Loss of genomic methylation causes p53-dependent apoptosis and epigenetic deregulation. Jackson-Grusby, L., Beard, C., Possemato, R., Tudor, M., Fambrough, D., Csankovszki, G., Dausman, J., Lee, P., Wilson, C., Lander, E., Jaenisch, R. Nat. Genet. (2001) [Pubmed]
  34. DNA methyltransferase Dnmt1 associates with histone deacetylase activity. Fuks, F., Burgers, W.A., Brehm, A., Hughes-Davies, L., Kouzarides, T. Nat. Genet. (2000) [Pubmed]
  35. Regulation of DNA methylation of Rasgrf1. Yoon, B.J., Herman, H., Sikora, A., Smith, L.T., Plass, C., Soloway, P.D. Nat. Genet. (2002) [Pubmed]
  36. Mutations in ATRX, encoding a SWI/SNF-like protein, cause diverse changes in the pattern of DNA methylation. Gibbons, R.J., McDowell, T.L., Raman, S., O'Rourke, D.M., Garrick, D., Ayyub, H., Higgs, D.R. Nat. Genet. (2000) [Pubmed]
  37. Histone and DNA methylation defects at Hox genes in mice expressing a SET domain-truncated form of Mll. Terranova, R., Agherbi, H., Boned, A., Meresse, S., Djabali, M. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  38. Activation of a nonexpressed hypoxanthine phosphoribosyltransferase allele in mutant H23 HeLa cells by agents that inhibit DNA methylation. Ivarie, R., Morris, J.A. Mol. Cell. Biol. (1986) [Pubmed]
  39. Cloning and characterization of EphA3 (Hek) gene promoter: DNA methylation regulates expression in hematopoietic tumor cells. Dottori, M., Down, M., Hüttmann, A., Fitzpatrick, D.R., Boyd, A.W. Blood (1999) [Pubmed]
  40. Allelic inactivation of the pseudoautosomal gene SYBL1 is controlled by epigenetic mechanisms common to the X and Y chromosomes. Matarazzo, M.R., De Bonis, M.L., Gregory, R.I., Vacca, M., Hansen, R.S., Mercadante, G., D'Urso, M., Feil, R., D'Esposito, M. Hum. Mol. Genet. (2002) [Pubmed]
  41. Hypermethylation of multiple genes in pancreatic adenocarcinoma. Ueki, T., Toyota, M., Sohn, T., Yeo, C.J., Issa, J.P., Hruban, R.H., Goggins, M. Cancer Res. (2000) [Pubmed]
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