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Gene Review

VAMP7  -  vesicle-associated membrane protein 7

Homo sapiens

Synonyms: SYBL1, Synaptobrevin-like protein 1, TI-VAMP, TIVAMP, Tetanus-insensitive VAMP, ...
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Disease relevance of SYBL1


Psychiatry related information on SYBL1


High impact information on SYBL1


Biological context of SYBL1

  • Although it is unclear at present how this allele-specific silencing comes about, the data also indicate that the epigenetic features of the 'Y inactivation' of SYBL1 are mechanistically similar to those associated with X-chromosome inactivation [6].
  • Combined, our data suggest that specific combinations of histone methylation and acetylation are involved in the somatic maintenance of permissive and repressed chromatin states at SYBL1 [6].
  • In ICF syndrome, a human disease affecting DNA methylation, SYBL1 escapes from silencing and this correlates with altered patterns of histone methylation and acetylation [6].
  • Allelic inactivation of the pseudoautosomal gene SYBL1 is controlled by epigenetic mechanisms common to the X and Y chromosomes [6].
  • Band shift and transient reporter gene assays indicate a strong role of two of these evolutionary conserved regions in regulating SYBL1 transcription [7].

Anatomical context of SYBL1

  • The results reported here clarify that a Staf-zinc finger family factor, together with the CAAT factor, is the major nuclear protein bound to the SYBL1 promoter region and is responsible for its regulation in HeLa cells, thus identifying the basic control of SYBL1 transcription [7].
  • SYBL1, which maps to the Xq pseudoautosomal region (PAR), encodes a member of the synaptobrevin family of proteins involved in synaptic vesicle docking, exocytosis, and membrane transport [2].
  • So far, only one SNARE, VAMP7, has been localized to late endosomes (LEs), where it is proposed to mediate trafficking of epidermal growth factor receptor to LEs and lysosomes [8].
  • In epithelial cells, TI-VAMP-containing vesicles were concentrated in the apical domain, and the protein was detected at the apical plasma membrane by immunogold labeling on ultrathin cryosections [9].
  • Antibodies to syntaxin 8 and a soluble recombinant VAMP7 fragment both inhibit in vitro reconstituted D. discoideum endosome fusion [10].

Associations of SYBL1 with chemical compounds


Regulatory relationships of SYBL1

  • Redistribution of TI-VAMP in the ER of syntaxin-1-expressing cells was microtubule dependent and impaired the trafficking of CD63, a cargo of TI-VAMP-containing vesicles [14].
  • Furthermore, we report that Cdc42 activates exocytosis of pHLuorin tagged TI-VAMP in an actin-dependent manner [15].
  • We report that MT1-MMP-dependent matrix degradation at invadopodia is regulated by the v-SNARE TI-VAMP/VAMP7, hence providing the molecular inventory mediating focal degradative activity of cancer cells [16].

Other interactions of SYBL1


Analytical, diagnostic and therapeutic context of SYBL1


  1. A dual mechanism controlling the localization and function of exocytic v-SNAREs. Martinez-Arca, S., Rudge, R., Vacca, M., Raposo, G., Camonis, J., Proux-Gillardeaux, V., Daviet, L., Formstecher, E., Hamburger, A., Filippini, F., D'Esposito, M., Galli, T. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  2. Association between a polymorphism in the pseudoautosomal X-linked gene SYBL1 and bipolar affective disorder. Müller, D.J., Schulze, T.G., Jahnes, E., Cichon, S., Krauss, H., Kesper, K., Held, T., Maier, W., Propping, P., Nöthen, M.M., Rietschel, M. Am. J. Med. Genet. (2002) [Pubmed]
  3. A synaptobrevin-like gene in the Xq28 pseudoautosomal region undergoes X inactivation. D'Esposito, M., Ciccodicola, A., Gianfrancesco, F., Esposito, T., Flagiello, L., Mazzarella, R., Schlessinger, D., D'Urso, M. Nat. Genet. (1996) [Pubmed]
  4. Longins and their longin domains: regulated SNAREs and multifunctional SNARE regulators. Rossi, V., Banfield, D.K., Vacca, M., Dietrich, L.E., Ungermann, C., D'Esposito, M., Galli, T., Filippini, F. Trends Biochem. Sci. (2004) [Pubmed]
  5. VAMP-7 mediates vesicular transport from endosomes to lysosomes. Advani, R.J., Yang, B., Prekeris, R., Lee, K.C., Klumperman, J., Scheller, R.H. J. Cell Biol. (1999) [Pubmed]
  6. Allelic inactivation of the pseudoautosomal gene SYBL1 is controlled by epigenetic mechanisms common to the X and Y chromosomes. Matarazzo, M.R., De Bonis, M.L., Gregory, R.I., Vacca, M., Hansen, R.S., Mercadante, G., D'Urso, M., Feil, R., D'Esposito, M. Hum. Mol. Genet. (2002) [Pubmed]
  7. Human synaptobrevin-like 1 gene basal transcription is regulated through the interaction of selenocysteine tRNA gene transcription activating factor-zinc finger 143 factors with evolutionary conserved cis-elements. Di Leva, F., Ferrante, M.I., Demarchi, F., Caravelli, A., Matarazzo, M.R., Giacca, M., D'Urso, M., D'Esposito, M., Franzé, A. J. Biol. Chem. (2004) [Pubmed]
  8. Differential roles of syntaxin 7 and syntaxin 8 in endosomal trafficking. Prekeris, R., Yang, B., Oorschot, V., Klumperman, J., Scheller, R.H. Mol. Biol. Cell (1999) [Pubmed]
  9. A novel tetanus neurotoxin-insensitive vesicle-associated membrane protein in SNARE complexes of the apical plasma membrane of epithelial cells. Galli, T., Zahraoui, A., Vaidyanathan, V.V., Raposo, G., Tian, J.M., Karin, M., Niemann, H., Louvard, D. Mol. Biol. Cell (1998) [Pubmed]
  10. Syntaxin 7, syntaxin 8, Vti1 and VAMP7 (vesicle-associated membrane protein 7) form an active SNARE complex for early macropinocytic compartment fusion in Dictyostelium discoideum. Bogdanovic, A., Bennett, N., Kieffer, S., Louwagie, M., Morio, T., Garin, J., Satre, M., Bruckert, F. Biochem. J. (2002) [Pubmed]
  11. Multiple binding of methyl-CpG and polycomb proteins in long-term gene silencing events. Matarazzo, M.R., De Bonis, M.L., Strazzullo, M., Cerase, A., Ferraro, M., Vastarelli, P., Ballestar, E., Esteller, M., Kudo, S., D'Esposito, M. J. Cell. Physiol. (2007) [Pubmed]
  12. Harboring of Particulate Allergens within Secretory Compartments by Mast Cells following IgE/Fc{epsilon}RI-Lipid Raft-Mediated Phagocytosis. Shin, J.S., Shelburne, C.P., Jin, C., Lefurgey, E.A., Abraham, S.N. J. Immunol. (2006) [Pubmed]
  13. Vesicle-associated membrane protein 7 is expressed in intestinal ER. Siddiqi, S.A., Mahan, J., Siddiqi, S., Gorelick, F.S., Mansbach, C.M. J. Cell. Sci. (2006) [Pubmed]
  14. Ectopic expression of syntaxin 1 in the ER redirects TI-VAMP- and cellubrevin-containing vesicles. Martinez-Arca, S., Proux-Gillardeaux, V., Alberts, P., Louvard, D., Galli, T. J. Cell. Sci. (2003) [Pubmed]
  15. Cdc42 and actin control polarized expression of TI-VAMP vesicles to neuronal growth cones and their fusion with the plasma membrane. Alberts, P., Rudge, R., Irinopoulou, T., Danglot, L., Gauthier-Rouvière, C., Galli, T. Mol. Biol. Cell (2006) [Pubmed]
  16. MT1-MMP-dependent invasion is regulated by TI-VAMP/VAMP7. Steffen, A., Le Dez, G., Poincloux, R., Recchi, C., Nassoy, P., Rottner, K., Galli, T., Chavrier, P. Curr. Biol. (2008) [Pubmed]
  17. Differential expression pattern of XqPAR-linked genes SYBL1 and IL9R correlates with the structure and evolution of the region. D'Esposito, M., Matarazzo, M.R., Ciccodicola, A., Strazzullo, M., Mazzarella, R., Quaderi, N.A., Fujiwara, H., Ko, M.S., Rowe, L.B., Ricco, A., Archidiacono, N., Rocchi, M., Schlessinger, D., D'Urso, M. Hum. Mol. Genet. (1997) [Pubmed]
  18. Maintenance of X- and Y-inactivation of the pseudoautosomal (PAR2) gene SPRY3 is independent from DNA methylation and associated to multiple layers of epigenetic modifications. De Bonis, M.L., Cerase, A., Matarazzo, M.R., Ferraro, M., Strazzullo, M., Hansen, R.S., Chiurazzi, P., Neri, G., D'Esposito, M. Hum. Mol. Genet. (2006) [Pubmed]
  19. Altered methylation pattern of the G6 PD promoter in Rett syndrome. Huppke, P., Bohlander, S., Krämer, N., Laccone, F., Hanefeld, F. Neuropediatrics. (2002) [Pubmed]
  20. DNA methylation in transcriptional repression of two differentially expressed X-linked genes, GPC3 and SYBL1. Huber, R., Hansen, R.S., Strazzullo, M., Pengue, G., Mazzarella, R., D'Urso, M., Schlessinger, D., Pilia, G., Gartler, S.M., D'Esposito, M. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  21. Characterization of two long vesicle-associated membrane proteins or longins genes from Entamoeba histolytica. Tamayo, E.M., Ondarza, R.N. Arch. Med. Res. (2004) [Pubmed]
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