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Gene Review

DSCR4  -  Down syndrome critical region 4

Homo sapiens

Synonyms: DCRB, DSCRB, Down syndrome critical region protein 4, Down syndrome critical region protein B
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High impact information on DSCR4


Other interactions of DSCR4

  • We show that while DSCR4 and DSCR8 are essentially co-expressed, their shared LTR promoter is more active in the sense than the antisense orientation [3].

Analytical, diagnostic and therapeutic context of DSCR4

  • Northern blot analysis showed that DCRB is mainly expressed in the placenta, in which a major 1.1-kb band and a minor 2.0-kb band were detected [2].


  1. Comparative genomic sequence analysis of the human chromosome 21 Down syndrome critical region. Toyoda, A., Noguchi, H., Taylor, T.D., Ito, T., Pletcher, M.T., Sakaki, Y., Reeves, R.H., Hattori, M. Genome Res. (2002) [Pubmed]
  2. A novel gene isolated from human placenta located in Down syndrome critical region on chromosome 21. Nakamura, A., Hattori, M., Sakaki, Y. DNA Res. (1997) [Pubmed]
  3. Transcription of two human genes from a bidirectional endogenous retrovirus promoter. Dunn, C.A., Romanish, M.T., Gutierrez, L.E., van de Lagemaat, L.N., Mager, D.L. Gene (2006) [Pubmed]
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