Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

DSCR4 - Down syndrome critical region 4

Homo sapiens

Synonyms: DCRB, DSCRB, Down syndrome critical region protein 4, Down syndrome critical region protein B

Nakamura, A. et al., Toyoda, A. et al., Dunn, C.A. et al.

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High impact information on DSCR4

Models for two human genes, DSCR4 and DSCR8, are not supported by conserved sequence, and close examination indicates that low-level transcripts from these loci are unlikely to encode proteins [1].
The gene, designated DCRB (Down syndrome Critical Region gene B), consisted of three exons of 1095 bp in total and encoded a large open reading frame of 118 amino acid residues [2].

Other interactions of DSCR4

We show that while DSCR4 and DSCR8 are essentially co-expressed, their shared LTR promoter is more active in the sense than the antisense orientation [3].

Analytical, diagnostic and therapeutic context of DSCR4

Northern blot analysis showed that DCRB is mainly expressed in the placenta, in which a major 1.1-kb band and a minor 2.0-kb band were detected [2].

References

Comparative genomic sequence analysis of the human chromosome 21 Down syndrome critical region. Toyoda, A., Noguchi, H., Taylor, T.D., Ito, T., Pletcher, M.T., Sakaki, Y., Reeves, R.H., Hattori, M. Genome Res. (2002) [Pubmed]
A novel gene isolated from human placenta located in Down syndrome critical region on chromosome 21. Nakamura, A., Hattori, M., Sakaki, Y. DNA Res. (1997) [Pubmed]
Transcription of two human genes from a bidirectional endogenous retrovirus promoter. Dunn, C.A., Romanish, M.T., Gutierrez, L.E., van de Lagemaat, L.N., Mager, D.L. Gene (2006) [Pubmed]

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