Disease relevance of DSCR8

• The MMA1 gene family of cancer-testis antigens has multiple alternative splice variants: characterization of their expression profile, the genomic organization, and transcript properties [1].
• Clinically, the lesions evolve from diffuse hyper-pigmentation to brown-black macules, to nodules of increasing size, to overt malignant melanoma associated with metastases, wasting, and death [2].
• Inhibition of macrophage migration by choroidal malignant melanoma-associated antigens in patients with unveal melanoma [3].
• A patient who had malignant melanoma associated with the hypereosinophilic syndrome died of cardiovascular thrombotic lesions [4].
• Malignant melanoma associated with human immunodeficiency virus infection in three homosexual men [5].

High impact information on DSCR8

• Models for two human genes, DSCR4 and DSCR8, are not supported by conserved sequence, and close examination indicates that low-level transcripts from these loci are unlikely to encode proteins [6].
• We identified an expressed sequence tag (EST), which we called malignant melanoma-associated 1 (MMA-1a), showing evident differential expression between the 2 cell lines [7].
• Overall and site-specific risk of malignant melanoma associated with nevus counts at different body sites: a multicenter case-control study of the German Central Malignant-Melanoma Registry [8].
• Although no genetic diseases of connective tissue map to this location, the malignant melanoma-associated surface antigen mel-CSPG is located here; mel-CSPG is a chondroitin sulfate proteoglycan [9].
• The most common site of malignant melanoma associated with this entity is in the choroid [10].

Chemical compound and disease context of DSCR8

• Despite the growing list of xenogeneic monoclonal antibodies (MAb) that recognize malignant melanoma-associated antigens (MAA) in formalin-fixed, paraffin-embedded tissue, none has been able to detect epitopes found in malignant melanomas and not in melanocytic nevi [11].
• We assessed the risk of cutaneous malignant melanoma associated with the presence of ovulatory abnormalities and with the use of ovulation-inducing agents (such as clomiphene citrate) in a cohort of 3,837 women evaluated at infertility clinics in Seattle, WA, between 1974 and 1985 [12].
• Expression of thymidine phosphorylase in choroidal malignant melanoma associated with neovascular glaucoma [13].

Biological context of DSCR8

• Argyrophilic nucleolar organizer region counts in malignant melanoma associated with benign intradermal nevus [14].

Anatomical context of DSCR8

• CONCLUSIONS: DMM of the oral mucosa is a rare, often unrecognized, form of malignant melanoma associated with a fibrosarcoma-like morphologic appearance and abundant collagenization [15].
• Although we came to no firm conclusion as to whether the malignant melanoma in the present case was preceded by melanosis (radial proliferation of atypical melanocytes), to our knowledge this is the first description of lacrimal sac malignant melanoma associated with a lesion of this kind in the surrounding epithelium [16].
• Malignant melanoma associated with lichen sclerosus in the vulva of a 10-year-old [17].

Other interactions of DSCR8

• Two cases of malignant melanoma associated with neurofibromatosis in two first-degree female relatives from a family with familial atypical multiple mole melanoma (FAMMM) syndrome are presented [18].
• Prolonged survival in metastatic malignant melanoma associated with vitiligo [19].
• A rare presentation of hypercalcemia secondary to the probable ectopic production of parathormone by a malignant melanoma associated with a pulmonary carcinoid is discussed [20].
• We also reviewed 26 cases of malignant melanoma associated with Werner syndrome (WS), including ours [21].

References