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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

PKDREJ  -  polycystin (PKD) family receptor for egg...

Homo sapiens

Synonyms: PKD and REJ homolog, Polycystic kidney disease and receptor for egg jelly-related protein
 
 
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High impact information on PKDREJ

  • PKDREJ expression has been detected only in the mammalian testis, where it is restricted to the spermatogenic lineage and retained in mature sperm [1].
  • The third gene, PKDREJ, encodes a putative 2253 amino acid protein and shows about 35% similarity to both polycystin-1 and polycystin-2 [2].
  • Further analysis revealed one novel gene, PKD2L2, located on chromosome band 5q31, and two recently described genes, PKD2L and PKDREJ, located on chromosome bands 10q31 and 22q13.3, respectively [2].

References

  1. Functional characterization of PKDREJ, a male germ cell-restricted polycystin. Sutton, K.A., Jungnickel, M.K., Ward, C.J., Harris, P.C., Florman, H.M. J. Cell. Physiol. (2006) [Pubmed]
  2. Genes homologous to the autosomal dominant polycystic kidney disease genes (PKD1 and PKD2). Veldhuisen, B., Spruit, L., Dauwerse, H.G., Breuning, M.H., Peters, D.J. Eur. J. Hum. Genet. (1999) [Pubmed]
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