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High impact information on HMG1L3
- In addition to the HMG1L3 insertion, Old World monkey genomes also contain an Alu sequence within the last SP100-HMG intron [1].
- In Old World monkeys, apes and humans one of these variants is extended by a retroprocessed pseudogene, HMG1L3, whose antecedent gene is a member of the family of high-mobility-group proteins, HMG1 [1].
Analytical, diagnostic and therapeutic context of HMG1L3
- RESULTS: PCR amplifications confirm that the HMG1L3 retrotransposition into the SP100 locus occurred after divergence of New World and Old World monkey lineages, some 35-40 million years ago [1].
References
- Molecular archeology of an SP100 splice variant revisited: dating the retrotranscription and Alu insertion events. Devor, E.J. Genome Biol. (2001) [Pubmed]
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