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Disease relevance of Cercopithecidae


Psychiatry related information on Cercopithecidae


High impact information on Cercopithecidae

  • Here we use both computational and experimental approaches to address these questions in a study of the pancreatic ribonuclease gene (RNASE1) and its duplicate gene (RNASE1B) in a leaf-eating colobine monkey, douc langur [7].
  • The EDN/ECP gene pair arose from a recent duplication event that occurred after the divergence of New World and Old World monkeys [8].
  • More recent transfers involving the entire cytochrome b gene have also occurred in the Old World monkeys [9].
  • To examine the basis for these shared properties, we sequenced langur stomach lysozyme and compared it to other lysozymes of known sequence [10].
  • The human immune system DRB1 genes are extremely polymorphic, with gene lineages that coalesce into an ancestor who lived around 60 million years ago, a time before the divergence of the apes from the Old World monkeys [11].

Chemical compound and disease context of Cercopithecidae


Biological context of Cercopithecidae


Anatomical context of Cercopithecidae


Associations of Cercopithecidae with chemical compounds

  • To investigate this possibility, we injected 11 adult Old World monkeys of different ages (5-23 years) with the thymidine analog bromodeoxyuridine and examined the fate of the labeled cells at different survival times by using neuronal and glial markers [26].
  • Old world monkeys are antigenically deficient in Clq,C1s, C9, and variably deficient in C4, C3, and C8 [27].
  • Gal-13 has been used to demonstrate that the Gal alpha 1-3Gal ceramide pentahexoside has been evolutionarily conserved in red cells of animals up to the stage of New World monkeys but is not found in Old World monkey red cells.(ABSTRACT TRUNCATED AT 400 WORDS)[28]
  • Because only arginine has been found at position 104 in gamma-chains of Old World monkeys, it may represent the ancestral residue lost in gorilla and human G gamma-chains and in the human A gamma-chain [29].
  • BACKGROUND: Naturally occurring antibodies (Nabs) that bind to terminal galactose alpha1,3-galactose carbohydrate structures (Gal) are present in humans and Old World monkeys but are negatively regulated in other mammalian species because they express Gal epitopes on their cell surfaces [30].

Gene context of Cercopithecidae

  • To this end, we compared CCR5 structure/evolution and regulation among humans, apes, Old World Monkeys, and New World Monkeys [31].
  • After this separation, the ancestral DRB1 gene of the DRw52 group duplicated in the Old World monkey lineage to give rise to genes at three loci at least, while in the ape lineage this gene may have remained single and diverged into a number of alleles instead [32].
  • For example, the IL8 proteins from two Old World monkeys are as similar to one another as they are to the IL8 protein from humans, and all observed nucleotide differences between the IL8 genes of the two monkeys cause amino acid changes; in other words, there are no synonymous differences between them [33].
  • All of the primate species tested, specifically, Old World monkeys (OWM) and apes, have orthologues of human CD209 [34].
  • The emergence of INSL4 gene and genomic insertion of HERV appear to have occurred after the divergence of New World and Old World monkeys ( approximately 45 million years ago) [35].

Analytical, diagnostic and therapeutic context of Cercopithecidae


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  2. The Old World monkey DAZ (Deleted in AZoospermia) gene yields insights into the evolution of the DAZ gene cluster on the human Y chromosome. Gromoll, J., Weinbauer, G.F., Skaletsky, H., Schlatt, S., Rocchietti-March, M., Page, D.C., Nieschlag, E. Hum. Mol. Genet. (1999) [Pubmed]
  3. Cyclophilin A Renders Human Immunodeficiency Virus Type 1 Sensitive to Old World Monkey but Not Human TRIM5{alpha} Antiviral Activity. Keckesova, Z., Ylinen, L.M., Towers, G.J. J. Virol. (2006) [Pubmed]
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  5. Retrovirus restriction by TRIM5alpha variants from Old World and New World primates. Song, B., Javanbakht, H., Perron, M., Park, D.H., Park, d.o. .H., Stremlau, M., Sodroski, J. J. Virol. (2005) [Pubmed]
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  8. Rapid evolution of a unique family of primate ribonuclease genes. Rosenberg, H.F., Dyer, K.D., Tiffany, H.L., Gonzalez, M. Nat. Genet. (1995) [Pubmed]
  9. Insertions and duplications of mtDNA in the nuclear genomes of Old World monkeys and hominoids. Collura, R.V., Stewart, C.B. Nature (1995) [Pubmed]
  10. Adaptive evolution in the stomach lysozymes of foregut fermenters. Stewart, C.B., Schilling, J.W., Wilson, A.C. Nature (1987) [Pubmed]
  11. The myth of Eve: molecular biology and human origins. Ayala, F.J. Science (1995) [Pubmed]
  12. Bone in the marmoset: a resemblance to vitamin D-dependent rickets, type II. Yamaguchi, A., Kohno, Y., Yamazaki, T., Takahashi, N., Shinki, T., Horiuchi, N., Suda, T., Koizumi, H., Tanioka, Y., Yoshiki, S. Calcif. Tissue Int. (1986) [Pubmed]
  13. Limitations in developing gossypol acetic acid as a male contraceptive. Lohiya, N.K., Sharma, K., Kumar, M., Sharma, S. Contraception. (1990) [Pubmed]
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  15. Antispermatogenic effects of tolnidamine in langur (Presbytis entellus). Lohiya, N.K., Ansari, A.S., Scorza Barcellona, P. Contraception. (1991) [Pubmed]
  16. A cascade of complex subtelomeric duplications during the evolution of the hominoid and Old World monkey genomes. van Geel, M., Eichler, E.E., Beck, A.F., Shan, Z., Haaf, T., van der Maarel, S.M., Frants, R.R., de Jong, P.J. Am. J. Hum. Genet. (2002) [Pubmed]
  17. The emergence of new DNA repeats and the divergence of primates. Minghetti, P.P., Dugaiczyk, A. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  18. Isolation and characterization of the human tyrosine aminotransferase gene. Rettenmeier, R., Natt, E., Zentgraf, H., Scherer, G. Nucleic Acids Res. (1990) [Pubmed]
  19. Structure and function of CC-chemokine receptor 5 homologues derived from representative primate species and subspecies of the taxonomic suborders Prosimii and Anthropoidea. Kunstman, K.J., Puffer, B., Korber, B.T., Kuiken, C., Smith, U.R., Kunstman, J., Stanton, J., Agy, M., Shibata, R., Yoder, A.D., Pillai, S., Doms, R.W., Marx, P., Wolinsky, S.M. J. Virol. (2003) [Pubmed]
  20. History of the Tfam gene in primates. D'Errico, I., Dinardo, M.M., Capozzi, O., De Virgilio, C., Gadaleta, G. Gene (2005) [Pubmed]
  21. Expression of the gamma-aminobutyric acid (GABA) plasma membrane transporter-1 in monkey and human retina. Casini, G., Rickman, D.W., Brecha, N.C. Invest. Ophthalmol. Vis. Sci. (2006) [Pubmed]
  22. beta-Endorphin levels in the cerebrospinal fluid of male talapoin monkeys in social groups related to dominance status and the luteinizing hormone response to naloxone. Martensz, N.D., Vellucci, S.V., Keverne, E.B., Herbert, J. Neuroscience (1986) [Pubmed]
  23. The distribution of enkephalin immunoreactive fibers and terminals in the monkey central nervous system: an immunohistochemical study. Haber, S., Elde, R. Neuroscience (1982) [Pubmed]
  24. The serotonin and norepinephrine innervation of primary visual cortex in the cynomolgus monkey (Macaca fascicularis). Kosofsky, B.E., Molliver, M.E., Morrison, J.H., Foote, S.L. J. Comp. Neurol. (1984) [Pubmed]
  25. Sialic acid concentration in the reproductive organs, pituitary gland and urine of the Indian langur monkey (Presbytis entellus entellus). Shandilya, L.N., Ramaswami, L.S., Shandilya, N. J. Endocrinol. (1977) [Pubmed]
  26. Hippocampal neurogenesis in adult Old World primates. Gould, E., Reeves, A.J., Fallah, M., Tanapat, P., Gross, C.G., Fuchs, E. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  27. Phylogeny of complement components in non-human primates. Schur, P.H., Connelly, A., Jones, T.C. J. Immunol. (1975) [Pubmed]
  28. Identification of erythrocyte Gal alpha 1-3Gal glycosphingolipids with a mouse monoclonal antibody, Gal-13. Galili, U., Basbaum, C.B., Shohet, S.B., Buehler, J., Macher, B.A. J. Biol. Chem. (1987) [Pubmed]
  29. The sequence of the gorilla fetal globin genes: evidence for multiple gene conversions in human evolution. Scott, A.F., Heath, P., Trusko, S., Boyer, S.H., Prass, W., Goodman, M., Czelusniak, J., Chang, L.Y., Slightom, J.L. Mol. Biol. Evol. (1984) [Pubmed]
  30. The structure of anti-Gal immunoglobulin genes in naïve and stimulated Gal knockout mice. Xu, H., Sharma, A., Chen, L., Harrison, C., Wei, Y., Chong, A.S., Logan, J.S., Byrne, G.W., Shama, A. Transplantation (2001) [Pubmed]
  31. Evolution of human and non-human primate CC chemokine receptor 5 gene and mRNA. Potential roles for haplotype and mRNA diversity, differential haplotype-specific transcriptional activity, and altered transcription factor binding to polymorphic nucleotides in the pathogenesis of HIV-1 and simian immunodeficiency virus. Mummidi, S., Bamshad, M., Ahuja, S.S., Gonzalez, E., Feuillet, P.M., Begum, K., Galvis, M.C., Kostecki, V., Valente, A.J., Murthy, K.K., Haro, L., Dolan, M.J., Allan, J.S., Ahuja, S.K. J. Biol. Chem. (2000) [Pubmed]
  32. Mhc-DRB genes of the pigtail macaque (Macaca nemestrina): implications for the evolution of human DRB genes. Zhu, Z.F., Vincek, V., Figueroa, F., Schönbach, C., Klein, J. Mol. Biol. Evol. (1991) [Pubmed]
  33. Isolation of novel GRO genes and a phylogenetic analysis of the CXC chemokine subfamily in mammals. Modi, W.S., Yoshimura, T. Mol. Biol. Evol. (1999) [Pubmed]
  34. Novel member of the CD209 (DC-SIGN) gene family in primates. Bashirova, A.A., Wu, L., Cheng, J., Martin, T.D., Martin, M.P., Benveniste, R.E., Lifson, J.D., KewalRamani, V.N., Hughes, A., Carrington, M. J. Virol. (2003) [Pubmed]
  35. Placenta-specific INSL4 expression is mediated by a human endogenous retrovirus element. Bièche, I., Laurent, A., Laurendeau, I., Duret, L., Giovangrandi, Y., Frendo, J.L., Olivi, M., Fausser, J.L., Evain-Brion, D., Vidaud, M. Biol. Reprod. (2003) [Pubmed]
  36. Natural infection by simian retrovirus-6 (SRV-6) in Hanuman langurs (Semnopithecus entellus) from two different geographical regions of India. Nandi, J.S., Tikute, S.A., Chhangani, A.K., Potdar, V.A., Tiwari-Mishra, M., Ashtekar, R.A., Kumari, J., Walimbe, A., Mohnot, S.M. Virology (2003) [Pubmed]
  37. Ultrastructural changes in the vas deferens of langur monkeys Presbytis entellus entellus after vas occlusion with styrene maleic anhydride and after its reversal. Manivannan, B., Mishra, P.K., Lohiya, N.K. Contraception. (1999) [Pubmed]
  38. Opiate antagonists stimulate affiliative behaviour in monkeys. Fabre-Nys, C., Meller, R.E., Keverne, E.B. Pharmacol. Biochem. Behav. (1982) [Pubmed]
  39. The causes of false-positives encountered during the screening of old-world primates for antibodies to human and simian retroviruses by ELISA. Pedersen, N.C., Lowenstine, L., Marx, P., Higgins, J., Baulu, J., McGuire, M., Gardner, M.B. J. Virol. Methods (1986) [Pubmed]
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