Gene Review:
yebU - rRNA (cytosine-C(5)-)-methyltransferase RsmF
Escherichia coli CFT073
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High impact information on yebU
- Purified recombinant YebU protein retains its specificity for C1407 in vitro, and methylates 30 S subunits (but not naked 16 S rRNA or 70 S ribosomes) isolated from yebU knockout strains [1].
- BLAST searches of the E.coli genome revealed a single gene, yebU, with sufficient similarity to rsmB to encode a putative m5C RNA methyltransferase [1].
- Here, we analysed the E.coli rRNAs by matrix assisted laser desorption/ionization mass spectrometry and show that inactivation of the yebU gene leads to loss of methylation at C1407 in 16 S rRNA, but does not interfere with methylation at C1962 in 23 S rRNA [1].
References
- YebU is a m5C methyltransferase specific for 16 S rRNA nucleotide 1407. Andersen, N.M., Douthwaite, S. J. Mol. Biol. (2006) [Pubmed]
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