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Gene Review

bioH  -  carboxylesterase BioH

Escherichia coli CFT073

 
 
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Disease relevance of bioH

 

High impact information on bioH

  • BioH is involved in biotin biosynthesis in Escherichia coli and had no previously known biochemical function [1].
  • An automated procedure was used to compare the structure of BioH with structural templates from a variety of different enzyme active sites [1].
  • From the sequence analysis, BioH is presumed to be a serine hydrolase, which belongs to the alpha/beta hydrolase-fold family comprising a wide variety of hydrolases including esterases [2].
  • A catalytic triad composed of a nucleophilic residue (Ser80), an acidic residue (Asp206), and histidine (His234) was conserved in BioH, and the nucleophilic residue Ser, a catalytic center, was situated in the consensus sequence of G-X-S-X-G-G, a nucleophile elbow [2].
 

Associations of bioH with chemical compounds

References

  1. Integrating structure, bioinformatics, and enzymology to discover function: BioH, a new carboxylesterase from Escherichia coli. Sanishvili, R., Yakunin, A.F., Laskowski, R.A., Skarina, T., Evdokimova, E., Doherty-Kirby, A., Lajoie, G.A., Thornton, J.M., Arrowsmith, C.H., Savchenko, A., Joachimiak, A., Edwards, A.M. J. Biol. Chem. (2003) [Pubmed]
  2. The Serratia marcescens bioH gene encodes an esterase. Akatsuka, H., Kawai, E., Sakurai, N., Omori, K. Gene (2003) [Pubmed]
  3. Purification and characterisation of the BIOH protein from the biotin biosynthetic pathway. Tomczyk, N.H., Nettleship, J.E., Baxter, R.L., Crichton, H.J., Webster, S.P., Campopiano, D.J. FEBS Lett. (2002) [Pubmed]
 
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