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Gene Review

gnd  -  6-phosphogluconate dehydrogenase

Escherichia coli CFT073

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High impact information on gnd

  • Enzymes from the pentose phosphate pathway (PPP) are potential drug targets for the development of new drugs against Trypanosoma brucei, the causative agent of African sleeping disease: for instance, the 6-phosphogluconate dehydrogenase is currently studied actively for such purposes [1].
  • Over-generated NADPH by the amplified gnd gene tended to depress the cell growth and PHB concentration [2].


  1. Three Dimensional Structure and Implications for the Catalytic Mechanism of 6-Phosphogluconolactonase from Trypanosoma brucei. Delarue, M., Duclert-Savatier, N., Miclet, E., Haouz, A., Giganti, D., Ouazzani, J., Lopez, P., Nilges, M., Stoven, V. J. Mol. Biol. (2007) [Pubmed]
  2. Metabolic engineering of pentose phosphate pathway in Ralstoniaeutropha for enhanced biosynthesis of poly-beta-hydroxybutyrate. Lee, J.N., Shin, H.D., Lee, Y.H. Biotechnol. Prog. (2003) [Pubmed]
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