High impact information on Wo

• In this article, we describe a transgenic neurological mutation, designated wocko (Wo), which disrupts the development of the inner ear [1].
• Because the integrated transgene provides a marker to clone the wocko mutation, the analysis of this mutant will give unique insight into the molecular genetics of inner ear development and into a broad class of neurological mutations that affect the inner ear [1].
• Wocko mice display a dominant behavioral phenotype that consists of hyperactivity, circling and head tossing [2].
• In this report, we examined the period of the circadian rhythm of wheel-running activity in a transgenic neurological mouse mutant, Wocko [2].

Analytical, diagnostic and therapeutic context of Wo

• Although low levels of transgene expression were detected using a sensitive PCR assay, several nonmutant pedigrees that contain the same construct also expressed the transgene in the inner ear, suggesting that low levels of transgene expression alone were not responsible for the wocko phenotype [1].

References