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Gene Review:

torC - cytochrome c-type protein torC

Escherichia coli CFT073

Simon, G. et al., Reyes, F. et al., Dos Santos, J.P. et al.

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Disease relevance of torC

NAPC has four haem c-binding sites and is homologous to the membrane-bound c-type cytochromes encoded by Pseudomonas stutzeri nirT and Escherichia coli torC genes [1].

High impact information on torC

Footprinting and gel-retardation experiments unambiguously demonstrated that TorR binds to the torC regulatory region [2].
The torC regulatory region contains four direct repeats of a decameric consensus motif designated the tor boxes [2].
Alteration by base substitutions of any of the four tor boxes in a plasmid containing a torC'-lacZ fusion dramatically reduces TorR-dependent torC expression [2].
The torC gene, located upstream from torA encodes a pentahemic c-type cytochrome, likely to be involved in electron transfer to the TorA terminal reductase [3].

References

Isolation of periplasmic nitrate reductase genes from Rhodobacter sphaeroides DSM 158: structural and functional differences among prokaryotic nitrate reductases. Reyes, F., Roldán, M.D., Klipp, W., Castillo, F., Moreno-Vivián, C. Mol. Microbiol. (1996) [Pubmed]
Binding of the TorR regulator to cis-acting direct repeats activates tor operon expression. Simon, G., Jourlin, C., Ansaldi, M., Pascal, M.C., Chippaux, M., Méjean, V. Mol. Microbiol. (1995) [Pubmed]
Molecular analysis of the trimethylamine N-oxide (TMAO) reductase respiratory system from a Shewanella species. Dos Santos, J.P., Iobbi-Nivol, C., Couillault, C., Giordano, G., Méjean, V. J. Mol. Biol. (1998) [Pubmed]

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