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Gene Review:

MYCNOS - MYCN opposite strand

Homo sapiens

Synonyms: CYMN, MYCN-AS1, N-CYM, N-cym protein, N-myc opposite strand, ...

Armstrong, B.C. et al., Scott, D. et al.

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Disease relevance of MYCNOS

Three genes have so far been identified, which are frequently co-amplified with MYCN in neuroblastoma, DDX1, NAG and N-cym [1].

High impact information on MYCNOS

We have isolated and characterized complementary DNA clones derived from a transcription unit, N-cym, located on the opposite DNA strand to N-myc, with extensive overlap existing between the 5' ends of the two transcription units [2].

Biological context of MYCNOS

The N-cym gene, which can encode a 109-amino acid protein, is expressed during fetal development, as well as in tumor cell lines containing amplified N-myc loci, where it is expressed at very high levels [2].

Anatomical context of MYCNOS

Although other examples of overlapping, opposite-strand eukaryotic genes exist, N-myc and N-cym are unique in that they appear to be coregulated in tumor cell lines under basal growth conditions and in response to the differentiating agent retinoic acid [2].

References

Genes co-amplified with MYCN in neuroblastoma: silent passengers or co-determinants of phenotype? Scott, D., Elsden, J., Pearson, A., Lunec, J. Cancer Lett. (2003) [Pubmed]
Isolation and characterization of complementary DNA for N-cym, a gene encoded by the DNA strand opposite to N-myc. Armstrong, B.C., Krystal, G.W. Cell Growth Differ. (1992) [Pubmed]

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