Gene Review:
MYCN - v-myc avian myelocytomatosis viral...
Homo sapiens
Synonyms:
BHLHE37, Class E basic helix-loop-helix protein 37, MODED, MYCNOT, N-myc, ...
De Smet,
Rieu,
Speleman,
Inge,
Glaudemans,
Cerignoli,
van Beusekom,
van Reeuwijk,
Ambrosi,
De Paepe,
Thompson,
Vandesompele,
White,
Yigit,
Philipp??,
Dominici,
Newbury-Ecob,
Coppens,
Marine,
Screpanti,
Rinne,
Rinaldi,
Massimi,
Vermeulen,
Giannini,
Van Maerken,
Lambertz,
Wu,
Sulman,
Maris,
De Clercq,
van Bokhoven,
Brodeur,
Gulino,
Frati,
Priebe,
Hogarty,
Liu,
Azizkhan,
Chiang,
Celli,
Mellone,
Harris,
Brunner,
- Natural killer T cells infiltrate neuroblastomas expressing the chemokine CCL2. Metelitsa, L.S., Wu, H.W., Wang, H., Yang, Y., Warsi, Z., Asgharzadeh, S., Groshen, S., Wilson, S.B., Seeger, R.C. J. Exp. Med. (2004)
- Mechanisms of embryonal tumor initiation: distinct roles for MycN expression and MYCN amplification. Hansford, L.M., Thomas, W.D., Keating, J.M., Burkhart, C.A., Peaston, A.E., Norris, M.D., Haber, M., Armati, P.J., Weiss, W.A., Marshall, G.M. Proc. Natl. Acad. Sci. U.S.A. (2004)
- Co-amplification of MYCN and a DEAD box gene (DDX1) in primary neuroblastoma. Squire, J.A., Thorner, P.S., Weitzman, S., Maggi, J.D., Dirks, P., Doyle, J., Hale, M., Godbout, R. Oncogene (1995)
- Mapping of chromosomal imbalances in gastric adenocarcinoma revealed amplified protooncogenes MYCN, MET, WNT2, and ERBB2. Nessling, M., Solinas-Toldo, S., Wilgenbus, K.K., Borchard, F., Lichter, P. Genes Chromosomes Cancer (1998)
- Oncogene MYCN regulates localization of NKT cells to the site of disease in neuroblastoma. Song, L., Ara, T., Wu, H.W., Woo, C.W., Reynolds, C.P., Seeger, R.C., DeClerck, Y.A., Thiele, C.J., Sposto, R., Metelitsa, L.S. J. Clin. Invest. (2007)
- Genes proximal and distal to MYCN are highly expressed in human neuroblastoma as visualized by comparative expressed sequence hybridization. Stock, C., Bozsaky, E., Watzinger, F., Poetschger, U., Orel, L., Lion, T., Kowalska, A., Ambros, P.F. Am. J. Pathol. (2008)
- Quantification of MYCN, DDX1, and NAG gene copy number in neuroblastoma using a real-time quantitative PCR assay. De Preter, K., Speleman, F., Combaret, V., Lunec, J., Laureys, G., Eussen, B.H., Francotte, N., Board, J., Pearson, A.D., De Paepe, A., Van Roy, N., Vandesompele, J. Mod. Pathol. (2002)
- Cell death signaling in the cerebellum in Creutzfeldt-Jakob disease. Puig, B., Ferrer, I. Acta Neuropathol. (2001)
- MYCN haploinsufficiency is associated with reduced brain size and intestinal atresias in Feingold syndrome. van Bokhoven, H., Celli, J., van Reeuwijk, J., Rinne, T., Glaudemans, B., van Beusekom, E., Rieu, P., Newbury-Ecob, R.A., Chiang, C., Brunner, H.G. Nat. Genet. (2005)
- Gain of chromosome arm 17q and adverse outcome in patients with neuroblastoma. Bown, N., Cotterill, S., Lastowska, M., O'Neill, S., Pearson, A.D., Plantaz, D., Meddeb, M., Danglot, G., Brinkschmidt, C., Christiansen, H., Laureys, G., Speleman, F., Nicholson, J., Bernheim, A., Betts, D.R., Vandesompele, J., Van Roy, N. N. Engl. J. Med. (1999)
- Expression of the gene for multidrug-resistance-associated protein and outcome in patients with neuroblastoma. Norris, M.D., Bordow, S.B., Marshall, G.M., Haber, P.S., Cohn, S.L., Haber, M. N. Engl. J. Med. (1996)
- E2F and Sp1/Sp3 Synergize but are not sufficient to activate the MYCN gene in neuroblastomas. Kramps, C., Strieder, V., Sapetschnig, A., Suske, G., Lutz, W. J. Biol. Chem. (2004)
- Expression of trkB in human neuroblastoma in relation to MYCN expression and retinoic acid treatment. Edsjö, A., Lavenius, E., Nilsson, H., Hoehner, J.C., Simonsson, P., Culp, L.A., Martinsson, T., Larsson, C., Påhlman, S. Lab. Invest. (2003)
- The MYCN protein of human neuroblastoma cells is phosphorylated by casein kinase II in the central region and at serine 367. Hamann, U., Wenzel, A., Frank, R., Schwab, M. Oncogene (1991)
- Induction of senescence in MYCN amplified neuroblastoma cell lines by hydroxyurea. Narath, R., Ambros, I.M., Kowalska, A., Bozsaky, E., Boukamp, P., Ambros, P.F. Genes Chromosomes Cancer (2007)
- The p53 regulatory gene MDM2 is a direct transcriptional target of MYCN in neuroblastoma. Slack, A., Chen, Z., Tonelli, R., Pule, M., Hunt, L., Pession, A., Shohet, J.M. Proc. Natl. Acad. Sci. U.S.A. (2005)
- Coamplification of DDX1 correlates with an improved survival probability in children with MYCN-amplified human neuroblastoma. Weber, A., Imisch, P., Bergmann, E., Christiansen, H. J. Clin. Oncol. (2004)
- Amplification of a DEAD box protein gene in retinoblastoma cell lines. Godbout, R., Squire, J. Proc. Natl. Acad. Sci. U.S.A. (1993)
- MYCN-directed centrosome amplification requires MDM2-mediated suppression of p53 activity in neuroblastoma cells. Slack, A.D., Chen, Z., Ludwig, A.D., Hicks, J., Shohet, J.M. Cancer Res. (2007)
- Caspase-9 and Apaf-1 are expressed and functionally active in human neuroblastoma tumor cell lines with 1p36 LOH and amplified MYCN. Teitz, T., Wei, T., Liu, D., Valentine, V., Valentine, M., Grenet, J., Lahti, J.M., Kidd, V.J. Oncogene (2002)
- High mobility group A1 is a molecular target for MYCN in human neuroblastoma. Giannini, G., Cerignoli, F., Mellone, M., Massimi, I., Ambrosi, C., Rinaldi, C., Dominici, C., Frati, L., Screpanti, I., Gulino, A. Cancer Res. (2005)
- E2F proteins regulate MYCN expression in neuroblastomas. Strieder, V., Lutz, W. J. Biol. Chem. (2003)
- Key role for p27Kip1, retinoblastoma protein Rb, and MYCN in polyamine inhibitor-induced G1 cell cycle arrest in MYCN-amplified human neuroblastoma cells. Wallick, C.J., Gamper, I., Thorne, M., Feith, D.J., Takasaki, K.Y., Wilson, S.M., Seki, J.A., Pegg, A.E., Byus, C.V., Bachmann, A.S. Oncogene (2005)
- Small-Molecule MDM2 Antagonists as a New Therapy Concept for Neuroblastoma. Van Maerken, T., Speleman, F., Vermeulen, J., Lambertz, I., De Clercq, S., De Smet, E., Yigit, N., Coppens, V., Philipp??, J., De Paepe, A., Marine, J.C., Vandesompele, J. Cancer Res. (2006)
- WP744 is a novel anthracycline with enhanced activity against neuroblastoma. Inge, T.H., Harris, N.L., Wu, J., Azizkhan, R.G., Priebe, W. J. Surg. Res. (2004)
- Expression of a MYCN-interacting isoform of the tumor suppressor BIN1 is reduced in neuroblastomas with unfavorable biological features. Tajiri, T., Liu, X., Thompson, P.M., Tanaka, S., Suita, S., Zhao, H., Maris, J.M., Prendergast, G.C., Hogarty, M.D. Clin. Cancer Res. (2003)
- Nestin is a potential mediator of malignancy in human neuroblastoma cells. Thomas, S.K., Messam, C.A., Spengler, B.A., Biedler, J.L., Ross, R.A. J. Biol. Chem. (2004)
- Absence of functional CD44 hyaluronan receptor on human NMYC-amplified neuroblastoma cells. Gross, N., Balmas, K., Brognara, C.B. Cancer Res. (1997)
- The high-mobility group transcription factor Sox10 interacts with the N-myc-interacting protein Nmi. Schlierf, B., Lang, S., Kosian, T., Werner, T., Wegner, M. J. Mol. Biol. (2005)
- Protein phosphorylation required for the formation of E2F complexes regulates N-myc transcription during differentiation of human embryonal carcinoma cells. Hara, E., Okamoto, S., Nakada, S., Taya, Y., Sekiya, S., Oda, K. Oncogene (1993)
- Specific phosphorylation of the acidic central region of the N-myc protein by casein kinase II. Hagiwara, T., Nakaya, K., Nakamura, Y., Nakajima, H., Nishimura, S., Taya, Y. Eur. J. Biochem. (1992)
- MDM2 as a critical effector of the MYCN oncogene in tumorigenesis. Slack, A., Shohet, J.M. Cell Cycle (2005)
- MYCN-mediated regulation of the MRP1 promoter in human neuroblastoma. Manohar, C.F., Bray, J.A., Salwen, H.R., Madafiglio, J., Cheng, A., Flemming, C., Marshall, G.M., Norris, M.D., Haber, M., Cohn, S.L. Oncogene (2004)
- BIN1 inhibits colony formation and induces apoptosis in neuroblastoma cell lines with MYCN amplification. Hogarty, M.D., Liu, X., Thompson, P.M., White, P.S., Sulman, E.P., Maris, J.M., Brodeur, G.M. Med. Pediatr. Oncol. (2000)
- New insights into testicular germ cell tumorigenesis from gene expression profiling. Skotheim, R.I., Monni, O., Mousses, S., Fosså, S.D., Kallioniemi, O.P., Lothe, R.A., Kallioniemi, A. Cancer Res. (2002)
- MYCN enhances P-gp/MDR1 gene expression in the human metastatic neuroblastoma IGR-N-91 model. Blanc, E., Goldschneider, D., Ferrandis, E., Barrois, M., Le Roux, G., Leonce, S., Douc-Rasy, S., Bénard, J., Raguénez, G. Am. J. Pathol. (2003)
- Genome-wide array CGH analysis of murine neuroblastoma reveals distinct genomic aberrations which parallel those in human tumors. Hackett, C.S., Hodgson, J.G., Law, M.E., Fridlyand, J., Osoegawa, K., de Jong, P.J., Nowak, N.J., Pinkel, D., Albertson, D.G., Jain, A., Jenkins, R., Gray, J.W., Weiss, W.A. Cancer Res. (2003)
- ID2 expression is not associated with MYCN amplification or expression in human neuroblastomas. Wang, Q., Hii, G., Shusterman, S., Mosse, Y., Winter, C.L., Guo, C., Zhao, H., Rappaport, E., Hogarty, M.D., Maris, J.M. Cancer Res. (2003)
- Minichromosome maintenance protein MCM7 is a direct target of the MYCN transcription factor in neuroblastoma. Shohet, J.M., Hicks, M.J., Plon, S.E., Burlingame, S.M., Stuart, S., Chen, S.Y., Brenner, M.K., Nuchtern, J.G. Cancer Res. (2002)
- Gene expression profiling in response to the histone deacetylase inhibitor BL1521 in neuroblastoma. de Ruijter, A.J., Meinsma, R.J., Bosma, P., Kemp, S., Caron, H.N., van Kuilenburg, A.B. Exp. Cell Res. (2005)