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Gene Review

PGRMC2  -  progesterone receptor membrane component 2

Homo sapiens

Synonyms: DG6, Membrane-associated progesterone receptor component 2, PMBP, Progesterone membrane-binding protein, Steroid receptor protein DG6
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Disease relevance of PGRMC2

  • Nodal metastasis was associated with high frequencies of copy number loss in genes PGRMC2 and LAMA3 and amplification in CDK6 and NCOA3(AIB1) [1].

High impact information on PGRMC2

  • In this context, a putative progesterone membrane binding protein (mPR) has been identified, recently [2].
  • Localization of a putative progesterone membrane binding protein in porcine hepatocytes [3].
  • To investigate the different phosphorescent promoting effects of organic emitters by various metal centers, a new ligand, 4,4'-diphenyl-6,6'-dimethyl-2,2'-bipyrimidine (pmbp), and its Zn(II), Hg(II), and Pt(II) complexes, [Zn(pmbp)(2)](ClO(4))(2)(1), Pt(pmbp)Ph(2)(2), Zn(pmbp)Cl(2)(3), and Hg(pmbp)Cl(2)(4) were synthesized [4].

Associations of PGRMC2 with chemical compounds


  1. Putative gene loci associated with carcinogenesis and metastasis of endocervical adenocarcinomas of uterus determined by conventional and array-based CGH. Hirai, Y., Utsugi, K., Takeshima, N., Kawamata, Y., Furuta, R., Kitagawa, T., Kawaguchi, T., Hasumi, K., Noda, T., Noda, S.T. Am. J. Obstet. Gynecol. (2004) [Pubmed]
  2. Specific progesterone binding to a membrane protein and related nongenomic effects on Ca2+-fluxes in sperm. Falkenstein, E., Heck, M., Gerdes, D., Grube, D., Christ, M., Weigel, M., Buddhikot, M., Meizel, S., Wehling, M. Endocrinology (1999) [Pubmed]
  3. Localization of a putative progesterone membrane binding protein in porcine hepatocytes. Falkenstein, E., Schmieding, K., Lange, A., Meyer, C., Gerdes, D., Welsch, U., Wehling, M. Cell. Mol. Biol. (Noisy-le-grand) (1998) [Pubmed]
  4. Blue phosphorescent Zn(II) and orange phosphorescent Pt(II) complexes of 4,4'-diphenyl-6,6'-dimethyl-2,2'-bipyrimidine. Liu, Q.D., Wang, R., Wang, S. Dalton transactions (Cambridge, England : 2003) (2004) [Pubmed]
  5. Interactions between progesterone and tumor necrosis factor-{alpha} in the regulation of primordial follicle assembly. Nilsson, E.E., Stanfield, J., Skinner, M.K. Reproduction (2006) [Pubmed]
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