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Gene Review

TUBGCP3  -  tubulin, gamma complex associated protein 3

Homo sapiens

Synonyms: 104p, GCP-3, GCP3, Gamma-ring complex protein 104 kDa, Gamma-tubulin complex component 3, ...
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High impact information on TUBGCP3

  • Recently, major advances have been achieved through the finding that gamma-tubulin, Spc97p and Spc98p form a conserved core that is probably responsible for microtubule nucleation, and by the discovery that a yeast GTBP is regulated in a cell-cycle-dependent manner and in response to an external signal [1].
  • Finally, affinity-purified antibodies against Spc98p inhibit microtubule nucleation on isolated centrosomes, as well as in microinjected cells, suggesting that this novel protein is indeed required for the nucleation reaction [2].

Anatomical context of TUBGCP3

  • The conservation of a complex involving gamma-tubulin, GCP2, and GCP3 from yeast to mammals suggests that structurally diverse microtubule organizing centers such as the yeast spindle pole body and the animal centrosome share a common molecular mechanism for microtubule nucleation [3].


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