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Gene Review:

dhfr - confers resistance to sulfonamides

Citrobacter freundii

Garvin, L.D. et al., Nørskov-Lauritsen, N. et al.

Nørskov-Lauritsen, Sandvang, Hedegaard, Fussing, Mortensen, Sperling-Petersen, Schønheyder,

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Disease relevance of dhfr

These were compared with the closely related Escherichia coli DHFR sequence [1].
The complete nucleotide and encoded amino acid sequences were determined for the dihydrofolate reductase (DHFR) from the bacteria Enterobacter aerogenes and Citrobacter freundii [1].

High impact information on dhfr

This epidemic strain harboured the aminoglycoside resistance genes aac(3)-II and ant(3")-I, with the latter located in tandem with a dihydrofolate reductase gene in a class I integron [2].

References

Temporal and topological clustering of diverged residues among enterobacterial dihydrofolate reductases. Garvin, L.D., Hardies, S.C. Mol. Biol. Evol. (1991) [Pubmed]
Clonal origin of aminoglycoside-resistant Citrobacter freundii isolates in a Danish county. Nørskov-Lauritsen, N., Sandvang, D., Hedegaard, J., Fussing, V., Mortensen, K.K., Sperling-Petersen, H.U., Schønheyder, H.C. J. Med. Microbiol. (2001) [Pubmed]

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