High impact information on SLU7

• We investigated this loss of fidelity by analysing spliceosomes assembled in the absence of hSlu7 [1].
• The RNA splicing factor hSlu7 is required for correct 3' splice-site choice [1].
• Here, we identify by bioinformatics and mutational analyses three functional domains of the hSlu7 protein that have distinct roles in its subcellular localization: a nuclear localization signal, a zinc-knuckle motif, and a lysine-rich region [2].
• Splicing protein hSlu7 is required for correct selection of the 3' splice site [2].
• Stress alters the subcellular distribution of hSlu7 and thus modulates alternative splicing [3].

Biological context of SLU7

• Although we found by RNAi knockdown that hSlu7 is not essential for cell viability, its nuclear concentration effects exon choice and inclusion:skipping ratio of alternative splicing [3].

References