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Gene Review

SLU7  -  SLU7 splicing factor homolog (S. cerevisiae)

Homo sapiens

Synonyms: 9G8, Pre-mRNA-splicing factor SLU7, hSlu7
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High impact information on SLU7

  • We investigated this loss of fidelity by analysing spliceosomes assembled in the absence of hSlu7 [1].
  • The RNA splicing factor hSlu7 is required for correct 3' splice-site choice [1].
  • Here, we identify by bioinformatics and mutational analyses three functional domains of the hSlu7 protein that have distinct roles in its subcellular localization: a nuclear localization signal, a zinc-knuckle motif, and a lysine-rich region [2].
  • Splicing protein hSlu7 is required for correct selection of the 3' splice site [2].
  • Stress alters the subcellular distribution of hSlu7 and thus modulates alternative splicing [3].

Biological context of SLU7


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